+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A reactor for high-throughput high-pressure nuclear magnetic resonance spectroscopy

A reactor for high-throughput high-pressure nuclear magnetic resonance spectroscopy

Review of Scientific Instruments 86(10): 104101

The design of a reactor for operando nuclear magnetic resonance (NMR) monitoring of high-pressure gas-liquid reactions is described. The Wisconsin High Pressure NMR Reactor (WiHP-NMRR) design comprises four modules: a sapphire NMR tube with titanium tube holder rated for pressures as high as 1000 psig (68 atm) and temperatures ranging from -90 to 90 °C, a gas circulation system that maintains equilibrium concentrations of dissolved gases during gas-consuming or gas-releasing reactions, a liquid injection apparatus that is capable of adding measured amounts of solutions to the reactor under high pressure conditions, and a rapid wash system that enables the reactor to be cleaned without removal from the NMR instrument. The WiHP-NMRR is compatible with commercial 10 mm NMR probes. Reactions performed in the WiHP-NMRR yield high quality, information-rich, and multinuclear NMR data over the entire reaction time course with rapid experimental turnaround.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 057092830

Download citation: RISBibTeXText

PMID: 26520969

DOI: 10.1063/1.4932676

Related references

Characterization of metabolites in intact Streptomyces citricolor culture supernatants using high-resolution nuclear magnetic resonance and directly coupled high-pressure liquid chromatography-nuclear magnetic resonance spectroscopy. Analytical Biochemistry 270(2): 220-230, 1999

An eight-coil high-frequency probehead design for high-throughput nuclear magnetic resonance spectroscopy. Journal of Magnetic Resonance 170(2): 206-212, 2004

Multiple solenoidal microcoil probes for high-sensitivity, high-throughput nuclear magnetic resonance spectroscopy. Analytical Chemistry 71(21): 4815-4820, 1999

A Multidisciplinary Approach to High Throughput Nuclear Magnetic Resonance Spectroscopy. Sensors 16(6), 2016

High resolution ¹⁹F{¹H} nuclear magnetic resonance spectroscopy and liquid chromatography-solid phase extraction-offline ¹H nuclear magnetic resonance spectroscopy for conclusive detection and identification of cyanide in water samples. Journal of Chromatography. a 1284: 88-99, 2013

Comparisons of the interactions between two analytes and two structurally similar chiral stationary phases using high-performance liquid chromatography, suspended-state high-resolution magic angle spinning nuclear magnetic resonance and solid-state nuclear magnetic resonance spectroscopy. Journal of Chromatography. A 1023(2): 215-223, 2004

Identification and quantification of metabolites of 2,3,5,6-tetrafluoro-4-trifluoromethylaniline in rat urine using 19F nuclear magnetic resonance spectroscopy, high-performance liquid chromatography-nuclear magnetic resonance spectroscopy and high-performance liquid chromatography-mass spectrometry. Journal of Chromatography B 748(1): 311-319, 1 October, 2000

Nuclear Magnetic Resonance Spectroscopy as a Dynamical Structural Probe of Hydrogen under High Pressure. Physical Review Letters 122(13): 135501, 2019

Flow injection proton nuclear magnetic resonance spectroscopy combined with pattern recognition methods: Implications for rapid structural studies and high throughput biochemical screening. Analytical Communications 34(11): 339-341, 1997

High-pressure high-resolution nuclear magnetic resonance. Effect of increased pressure on the proton chemical shift of biphenyl. Journal of Magnetic Resonance 39(2): 309-315, 1969

High-throughput nuclear magnetic resonance-based screening. Journal of Medicinal Chemistry 42(13): 2315-2317, 1999

Two approaches to high-resolution high-pressure nuclear magnetic resonance. Journal of Magnetic Resonance 29(1): 11-19, 1969

A high-pressure probe for high-resolution nuclear magnetic resonance. Journal of Magnetic Resonance 30(3): 571-576, 1969

Analyses of compound libraries obtained by high-throughput parallel synthesis: Strategy of quality control by high-performance liquid chromatography, mass spectrometry and nuclear magnetic resonance techniques. Journal of Chromatography B 725(1): 39-47, April 2, 1999

High-Pressure, High-Resolution Nuclear Magnetic Resonance (HPHR-NMR.): A Tool in Chemical Kinetics. Helvetica Chimica Acta 60(3): 1124-1127, 1977