+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Acute toxicity and anticonvulsant activity of liposomes containing nimodipine on pilocarpine-induced seizures in mice

Acute toxicity and anticonvulsant activity of liposomes containing nimodipine on pilocarpine-induced seizures in mice

Neuroscience Letters 585: 38-42

Nimodipine has been shown to have an inhibitory action on seizures and brain damage in rodents. However, the pharmaceutical applicability of this drug is limited by its low solubility in gastrointestinal fluids and high first-pass effect in the liver, which leads to low bioavailability. These difficulties can be overcome through the use of liposomes. The aim of the present study is to evaluate the toxicity and anticonvulsant activity of liposomes containing nimodipine (NMD-Lipo) on pilocarpine-induced seizures. NMD-Lipo was prepared using the lipid-film hydration method. Central nervous system toxicity of NMD-Lipo was assessed by Hippocratic screening. Systemic toxicity was evaluated by analyses of biochemical and hematological parameters and by observing possible signs of toxicity. The possible anticonvulsant activity was tested by the pilocarpine model. The administration of the NMD-Lipo at doses of 0.1, 1, and 10 mg/kg caused no toxicity in animals. Furthermore, NMD-Lipo prevented the installation of 100% of the pilocarpine-induced seizures and prevented the death of 100% of the mice treated with pilocarpine. These data shown that NMD-Lipo has an anticonvulsant activity significantly superior to free NMD, suggesting that the liposomes promoted a drug controlled release by improving its bioavailability and consequently increasing its pharmacological activity.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 057134778

Download citation: RISBibTeXText

PMID: 25445375

DOI: 10.1016/j.neulet.2014.11.025

Related references

Determination of the anticonvulsant activity of nimodipine against electroshock seizures in mice. Epilepsia 33(Suppl. 3): 78, 1992

Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice. Epilepsy and Behavior 62: 27-34, 2016

Anticonvulsant Effect of Swertiamarin Against Pilocarpine-Induced Seizures in Adult Male Mice. Neurochemical Research 42(11): 3103-3113, 2017

Inhibitory action of a calcium channel blocker (nimodipine) on seizures and brain damage induced by pilocarpine and lithium-pilocarpine in rats. Neuroscience Letters 235(1-2): 13-16, 1997

Blockade of the sodium calcium exchanger exhibits anticonvulsant activity in a pilocarpine model of acute seizures in rats. Brain Research 1366: 211-216, 2010

Influence of pilocarpine on the anticonvulsant activity of common antiepileptic drugs against maximal electroshock-induced seizures. Polish Journal of Pharmacology 47(Suppl. ): 126-127, 1995

Erythropoietin is anticonvulsant against kainic acid-induced seizures, but not pilocarpine, pentylenetetrazol, or electroshock seizures. Epilepsia 43(Suppl. 7): 103, 2002

Influence of imperatorin on the anticonvulsant activity and acute adverse-effect profile of lamotrigine in maximal electroshock-induced seizures and chimney test in mice. Pharmacological Reports 60(4): 566-573, 2008

Effect of acute and chronic treatment with milnacipran potentiates the anticonvulsant activity of conventional antiepileptic drugs in the maximal electroshock-induced seizures in mice. Psychopharmacology 207(4): 661-669, 2010

Antioxidant effect of nimodipine in young rats after pilocarpine-induced seizures. Pharmacology Biochemistry and Behavior 82(1): 11-16, 2005

Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. Indian Journal of Experimental Biology 37(4): 340-343, 1999

Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. Journal of Toxicological Sciences 43(11): 671-684, 2018

Only certain anticonvulsant drugs protect rats against seizures induced by pilocarpine. Society for Neuroscience Abstracts 12(2): 898, 1986

Anticonvulsant effects of nimodipine and two novel dihydropyridines (PCA 50922 and PCA 50941) against seizures elicited by pentylenetetrazole and electroconvulsive shock in mice. Brain Research 796(1-2): 311-314, 1998

Anticonvulsant properties of melatonin in the model of pilocarpine-induced seizures in rats. Society for Neuroscience Abstracts 26(1-2): Abstract No -376 7, 2000