+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response

Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response

Alcohol 51: 89-100

Adolescents are sensitive to the anxiolytic effect of ethanol, and evidence suggests that they may be more sensitive to stress than adults. Relatively little is known, however, about age-related differences in stress modulation of ethanol drinking or stress modulation of ethanol-induced sedation and hypnosis. We observed that chronic restraint stress transiently exacerbated free-choice ethanol drinking in adolescent, but not in adult, rats. Restraint stress altered exploration patterns of a light-dark box apparatus in adolescents and adults. Stressed animals spent significantly more time in the white area of the maze and made significantly more transfers between compartments than their non-stressed peers. Behavioral response to acute stress, on the other hand, was modulated by prior restraint stress only in adults. Adolescents, unlike adults, exhibited ethanol-induced motor stimulation in an open field. Stress increased the duration of loss of the righting reflex after a high ethanol dose, yet this effect was similar at both ages. Ethanol-induced sleep time was much higher in adult than in adolescent rats, yet stress diminished ethanol-induced sleep time only in adults. The study indicates age-related differences that may increase the risk for initiation and escalation in alcohol drinking.

(PDF emailed within 0-6 h: $19.90)

Accession: 057153130

Download citation: RISBibTeXText

PMID: 26830848

DOI: 10.1016/j.alcohol.2015.11.009

Related references

Effects of ethanol on locomotor depression and corticosterone release induced by restraint-stress: support for a stress-ethanol interaction. Pharmacology, Biochemistry, and Behavior 36(2): 273-278, 1990

Anxiety response and restraint-induced stress differentially affect ethanol intake in female adolescent rats. Neuroscience 334: 259-274, 2016

Effects of chronic ethanol consumption on the adrenocortical response to restraint stress. Anatomical Record 226(4): 109A-110A, 1990

The effects of captopril and naloxone on restraint-cold-stress- and ethanol-induced gastric lesions in rats. General Pharmacology 30(5): 701-704, 1998

Chronic intermittent ethanol exposure during adolescence: Effects on stress-induced social alterations and social drinking in adulthood. Brain Research 1654(Pt B): 145-156, 2016

Influence of age on effects induced by intermittent ethanol treatment on the ethanol drinking pattern and related neurochemical changes in the rat. Drug & Alcohol Dependence 22(1-2): 117-128, 1988

Predictors of high ethanol consumption in RIIbeta knock-out mice: assessment of anxiety and ethanol-induced sedation. Alcoholism, Clinical and Experimental Research 28(10): 1459-1468, 2004

Concomitant stress potentiates the preference for, and consumption of, ethanol induced by chronic pre-exposure to ethanol. Brazilian Journal of Medical and Biological Research 49(1): E5009-E5009, 2016

Stress related to repeated chronic ethanol exposure and withdrawal Effects on ethanol intake in C57BL/6J mice. Alcoholism Clinical & Experimental Research 27(5 Supplement): 16A, 2003

Long-term ethanol self-administration with repeated ethanol deprivation episodes changes ethanol drinking pattern and increases anxiety-related behaviour during ethanol deprivation in rats. Behavioural Pharmacology 9(1): 41-48, 1998

Content of endogenous ethanol in the blood and tissues of rats differing in their response to ethanol after immobilization induced stress. Vyestsi Akademii Navuk BSSR Syeryya Biyalahichnykh Navuk (4): 94-97, 1990

History of ethanol dependence determines long-term vulnerability to relapse induced by stress and ethanol-related cues in rats. Alcoholism Clinical & Experimental Research 24(5 Supplement): 51A, 2000

Increased anxiety, voluntary alcohol consumption and ethanol-induced place preference in mice following chronic psychosocial stress. Stress 16(4): 441-451, 2014

Effects of mild footshock stress on anxiety and ethanol drinking in three mouse strains. Alcoholism Clinical & Experimental Research 27(5 Supplement): 50A, 2003

Stress-Induced Enhancement of Ethanol Intake in C57BL/6J Mice with a History of Chronic Ethanol Exposure: Involvement of Kappa Opioid Receptors. Frontiers in Cellular Neuroscience 10: 45-45, 2016