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Alkyne hydroacylation: switching regioselectivity by tandem ruthenium catalysis

Alkyne hydroacylation: switching regioselectivity by tandem ruthenium catalysis

Journal of the American Chemical Society 137(9): 3157-3160

By using tandem Ru-catalysis, internal alkynes can be coupled with aldehydes for the synthesis of β,γ-unsaturated ketones. The catalyst promotes alkyne transformations with high regioselectivity, with examples that include the differentiation of a methyl vs ethyl substituent on the alkyne. Mechanistic studies suggest that the regioselectivity results from a selective allene formation that is governed by allylic strain.

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Accession: 057159294

Download citation: RISBibTeXText

PMID: 25608143

DOI: 10.1021/ja512015w

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