+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Altered Monoamine and Acylcarnitine Metabolites in HIV-Positive and HIV-Negative Subjects With Depression



Altered Monoamine and Acylcarnitine Metabolites in HIV-Positive and HIV-Negative Subjects With Depression



Journal of Acquired Immune Deficiency Syndromes 69(1): 18-28



Depression is a frequent comorbidity in HIV infection that has been associated with worse treatment outcomes and increased mortality. Recent studies suggest that increased innate immune activation and tryptophan catabolism are associated with higher risk of depression in HIV infection and other chronic inflammatory diseases, but the mechanisms leading to depression remain poorly understood. The severity of depressive symptoms was assessed by Beck Depression Inventory or Center for Epidemiological Studies Depression Scale. Untargeted metabolomic profiling of plasma from 104 subjects (68 HIV-positive and 36 HIV-negative) across 3 independent cohorts was performed using liquid or gas chromatography followed by mass spectrometry. Cytokine profiling was by Bioplex array. Bioinformatic analysis was performed in Metaboanalyst and R. Decreased monoamine metabolites (phenylacetate, 4-hydroxyphenylacetate) and acylcarnitines (propionylcarnitine, isobutyrylcarnitine, isovalerylcarnitine, 2-methylbutyrylcarnitine) in plasma distinguished depressed subjects from controls in HIV-positive and HIV-negative cohorts, and these alterations correlated with the severity of depressive symptoms. In HIV-positive subjects, acylcarnitines and other markers of mitochondrial function correlated inversely with tryptophan catabolism, a marker of interferon responses, suggesting interrelationships between inflammatory pathways, tryptophan catabolism, and metabolic alterations associated with depression. Altered metabolites mapped to pathways involved in monoamine metabolism, mitochondrial function, and inflammation, suggesting a model in which complex relationships between monoamine metabolism and mitochondrial bioenergetics contribute to biological mechanisms involved in depression that may be augmented by inflammation during HIV infection. Integrated approaches targeting inflammation, monoamine metabolism, and mitochondrial pathways may be important for prevention and treatment of depression in people with and without HIV.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057163465

Download citation: RISBibTeXText

PMID: 25942456

DOI: 10.1097/qai.0000000000000551


Related references

Biological markers in depression. Monoamine metabolites in urine of depressed patients and normal subjects. Pharmacopsychiatry 18(6): 347-350, 1985

Altered serous levels of monoamine neurotransmitter metabolites in patients with refractory and non-refractory depression. Neural Regeneration Research 7(14): 1113-1118, 2012

Relationships between 2h4 cd45ra and uchl1 cd45ro expression by normal blood cd4 positive cd8 negative cd4 negative cd8 positive cd4 negative cd8dim positive cd3 positive cd4 negative cd8 negative and cd3 negative cd4 negative cd8 negative lymphocytes. Clinical & Experimental Immunology 81(1): 149-155, 1990

Anxiety positive subjects show altered processing in the anterior insula during anticipation of negative stimuli. Human Brain Mapping 32(11): 1836-1846, 2011

Pharmacokinetics of oral moclobemide in healthy human subjects and effects on monoamine oxidase activity in platelets and excretion of urine monoamine metabolites. European Journal of Clinical Pharmacology 28(1): 89-96, 1985

Platelet monoamine oxidase B in family history positive and family history negative type 1 alcohol-dependent subjects. Alcohol and Alcoholism 37(6): 577-580, 2002

CSF monoamine metabolites in depression and schizophrenia. American Journal of Psychiatry 137(2): 174-180, 1980

CSF monoamine metabolites, depression, and suicide. Advances in Biochemical Psychopharmacology 39: 87-97, 1984

CSF monoamine metabolites in alcoholism: a comparative study with depression. Folia Psychiatrica et Neurologica Japonica 28(4): 347-354, 1974

Cerebrospinal fluid monoamine metabolites depression and suicide. Usdin, Et Al. (ed.). Advances In Biochemical Psychopharmacology, Vol. 39. Frontiers In Biochemical And Pharmacological Research In Depression, Meeting. Xxiii 458p. Raven Press: New York, N.y., Usa. Illus. 87-98, 1984

Human cd3 negative cd4 negative cd8 negative thymocytes differentiate into cd3 positive cd4 positive cd8 alpha positive beta positive cells in vitro in the presence of il 7. Journal of Cellular Biochemistry Suppl. (15 Part F): 59, 1991

Suicidal potential in depression: focus on CSF monoamine and purine metabolites. Psychopharmacology Bulletin 22(3): 656-660, 1986

Reduction of CSF monoamine metabolites in poststroke depression: a preliminary report. Journal of Neuropsychiatry and Clinical Neurosciences 4(4): 440-442, 1992

CSF monoamine metabolites and somatostatin in Alzheimer's disease and major depression. Biological Psychiatry 29(11): 1110-1118, 1991

Amino acids in plasma and CSF and monoamine metabolites in CSF: interrelationship in healthy subjects. Journal of Neurochemistry 42(3): 833-837, 1984