+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ambulatory Blood Pressures in Hypertensive Patients Treated With One Antihypertensive Agent: Differences Among Drug Classes and Among Drugs Belonging to the Same Class



Ambulatory Blood Pressures in Hypertensive Patients Treated With One Antihypertensive Agent: Differences Among Drug Classes and Among Drugs Belonging to the Same Class



Journal of Clinical Hypertension 17(11): 857-865



The authors investigated the differences in office and ambulatory blood pressure (BP) among major antihypertensive drug classes and among frequently used drugs in each class in 22,617 patients treated with monotherapy from the Spanish ABPM Registry. Using thiazides as the reference group, patients treated with calcium channel blockers have significantly (P<.01) elevated ambulatory BP and less ambulatory control after adjusting for confounders. Inside each class, no significant differences were observed among thiazides or angiotensin receptor blockers. Atenolol and bisoprolol among β-blockers, amlodipine among calcium channel blockers, and lisinopril and enalapril among angiotensin-converting enzyme inhibitors exhibited lower ambulatory BP and better control than other agents. Differences exist among antihypertensive drug classes and among different compounds in each class with respect to ambulatory BP control. This can help physicians choose among drug classes and among compounds in each class if BP reduction is the main objective of treatment.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057166625

Download citation: RISBibTeXText

PMID: 26205479

DOI: 10.1111/jch.12623


Related references

Seasonal variations in office and home blood pressures in hypertensive patients treated with antihypertensive drugs. Blood Pressure Monitoring 3(2): 101-106, 1998

Persistence of treatment and blood pressure control in elderly hypertensive patients treated with different classes of antihypertensive drugs. American Journal of Geriatric Cardiology 16(5): 280-286, 2007

Most individuals with treated blood pressures above target receive only one or two antihypertensive drug classes. Internal Medicine Journal 43(2): 137-143, 2013

The relationship of office and ambulatory systolic blood pressures and pulse pressures to cardiac structural parameters in never treated hypertensive subjects. American Journal of Hypertension 16(5 Part 2): 55A-56A, 2003

Office and ambulatory blood pressure control in hypertensive patients treated with different two-drug and three-drug combinations. Clinical and Experimental Hypertension 38(4): 409-414, 2016

Effects of COX-2 specific inhibition on systolic blood pressure in 1,092 older hypertensive patients according to antihypertensive drug class. Clinical Pharmacology & Therapeutics 71(2): P9, 2002

Class of antihypertensive drugs, blood pressure status, and risk of cardiovascular disease in hypertensive patients: a case-control study in Japan. Hypertension Research 28(10): 811-817, 2005

The repercussion of stopping reimbursement of olmésartan on antihypertensive drugs prescription and blood pressure control of treated hypertensive patients in France. Annales de Cardiologie et d'Angeiologie 67(3): 149-153, 2018

Effects of different classes of antihypertensive drugs on cerebral hemodynamics in elderly hypertensive patients. American Journal of Hypertension 18(12 Pt 1): 1621-1625, 2005

Blood pressure differences between home monitoring and daytime ambulatory values and their reproducibility in treated hypertensive stroke and TIA patients. American Heart Journal 207: 58-65, 2019

Ambulatory blood pressure valves vs trough-to-peak ratios to assess the antihypertensive efficacy of felodipine-ER, amlodipine, and nifedipine-GITS in ambulatory hypertensive patients. Clinical & Investigative Medicine 20(4 Suppl. ): S43, 1997

Effects of a lifestyle programme on ambulatory blood pressure and drug dosage in treated hypertensive patients: a randomized controlled trial. Journal of Hypertension 23(6): 1241-1249, 2005

The use of ambulatory blood pressure monitoring to evaluate antihypertensive drugs for drug approval. Blood Pressure Monitoring 1(3): 313-315, 1996

Queen Mary Utilization of Antihypertensive Drugs Study: use of antihypertensive drug classes in the hypertension clinic 1996-2004. British Journal of Clinical Pharmacology 60(1): 90-97, 2005

Comparison of office readings with 24 hour ambulatory blood pressures in hypertensive patients. Clinical Research 28(2): 550A, 1980