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An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene C(sp(3))-H bond insertion

An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene C(sp(3))-H bond insertion

Organic and Biomolecular Chemistry 13(17): 4851-4854

A method for convenient synthesis of N-alkyl-2-aryl-indole-3-carbaldehyde has been described. A variety of highly valuable indolyl aldehydes have been prepared through this method. Electron donating groups on both aromatic rings (anilinyl and benzyl) facilitate the formation of the desired products. A benzylic C-H insertion by rhodium carbene is the key step for this transformation.

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Accession: 057178942

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PMID: 25826185

DOI: 10.1039/c5ob00085h

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