EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Analysis of risk factors of recurrence of hepatocellular carcinoma after control of surgical-risk-factors



Analysis of risk factors of recurrence of hepatocellular carcinoma after control of surgical-risk-factors



Zhonghua Zhong Liu Za Zhi 36(8): 629-634



R0 resection, Pringle maneuver, intraoperative massive blood loss and perioperative blood transfusion have been definitely recognized to be surgery-related risk factors of recurrence of hepatocellular carcinoma (HCC) in recent years. The aim of this study was to investigate the post-operative risk factors of recurrence of HCC after control of the above mentioned risk factors. 288 consecutive HCC patients underwent hepatectomy with selective regional vascular occlusion by the same surgical team. All patients had R0 resection, less than 800 ml blood loss and had no perioperative blood transfusion. The clinical and pathological factors were retrospectively analyzed. The total 1-year, 3-year and 5-year disease-free survival rate (DFS) was 74.9%, 49.3% and 34.3%, respectively. Univariate analysis showed that serum gamma-glutamyl-transferase rise >55 U/L, AFP > 400 ng/ml, tumor diameter >5 cm, multi-focal lesions, satellite nodules, poor differentiation, microvascular invasion, envelope invasion, postoperative liver insufficiency, preoperative TACE and postoperative TACE were significantly associated with poor DFS. Multivariate Cox analyses revealed that tumor size, satellite nodules, poor differentiation, microvascular invasion and postoperative liver insufficiency were independent prognostic predictors associated with shorter DFS. According to the results of multivariate Cox analysis of 158 cases with at least one risk factor selected from the whole group, further analysis demonstrated that perioperative TACE was not significantly associated with the median DFS (P > 0.05 for all). Selective regional vascular occlusion may effectively control the surgiury-related risk factors of recurrence of HCC. Tumor features are the main affecting factors of DFS. Preoperative or postoperative TACE do not benefit patients who received curative resection.

(PDF emailed within 1 workday: $29.90)

Accession: 057192943

Download citation: RISBibTeXText

PMID: 25430033



Related references

Analysis of risk factors of recurrence in patients with BCLC 0-A hepatocellular carcinoma after surgical resection. Zhonghua Yi Xue Za Zhi 95(22): 1747-1750, 2016

Risk factors for early recurrence after surgical resection for hepatocellular carcinoma. Korean Journal of Hepatology 14(3): 371-380, 2008

Analysis of risk factors for recurrence of hepatocellular carcinoma after orthotopic liver transplantation. Transplantation Proceedings 27(1): 1245-1246, 1995

Risk factors and prognostic factors of local recurrence after radiofrequency ablation of hepatocellular carcinoma. Journal of the American College of Surgeons 207(1): 20-29, 2008

Risk factors of post-operative recurrence and adequate surgical approach to improve long-term outcomes of hepatocellular carcinoma. Hpb 15(1): 31-39, 2013

Analysis of the risk factors of untransplantable recurrence after primary curative resection for patients with hepatocellular carcinoma. Annals of Surgical Oncology 20(8): 2526-2533, 2013

Analysis of risk factors for tumor recurrence after liver transplantation for hepatocellular carcinoma: key role of immunosuppression. Liver Transplantation 11(5): 497-503, 2005

Prospective analysis of risk factors for survival and intrahepatic recurrence of hepatocellular carcinoma following ethanol injection. Journal of Hepatology 38(Supplement 2): 93, April, 2003

Early diffuse recurrence of hepatocellular carcinoma after percutaneous radiofrequency ablation: analysis of risk factors. European Radiology 23(1): 190-197, 2013

Intrahepatic recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: analysis of the pattern and risk factors. European Journal of Radiology 59(3): 432-441, 2006

Prospective analysis of risk factors for early intrahepatic recurrence of hepatocellular carcinoma following ethanol injection. Journal of Hepatology 32(2): 269-278, 2000

Liver resection for hepatocellular carcinoma on cirrhosis: univariate and multivariate analysis of risk factors for intrahepatic recurrence. Annals of Surgery 237(4): 536-543, 2003

Analysis of the risk factors for early death due to disease recurrence or progression within 1 year after hepatectomy in patients with hepatocellular carcinoma. World Journal of Surgical Oncology 10: 107-107, 2013

Risk factors for the recurrence of hepatocellular carcinoma after radiofrequency ablation of hepatocellular carcinoma in patients with hepatitis C. World Journal of Gastroenterology 11(14): 2174-2178, 2005

Non-B non-C Hepatocellular Carcinoma: the Risk Factors for Recurrence and the Types of Recurrence Following Hepatic Resection. Hepato-Gastroenterology 61(131): 762-770, 2015