EurekaMag
+ Translate
+ Most Popular
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
Observations on the Umaria marine bed
10 years of hearing conservation in the Royal Air Force
Chocolate crumb - dairy ingredient for milk chocolate
Effect of daily gelatin ingestion on human scalp hair
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
The composition of pampas-grass (Cortaderia argentea.)
The Accraian Series:
The mechanism of the Liebermann-Burchard reaction of sterols and triterpenes and their esters
Cerebrovascular Doppler ultrasound studies (cv-Doppler)
Toria: PT-303 - first national variety
Hair growth promoting activity of tridax procumbens
Productivity of Pekin x Khaki Campbell ducks
A stable cytosolic expression of VH antibody fragment directed against PVY NIa protein in transgenic potato plant confers partial protection against the virus
Solar treatment of wheat loose smut
Swimmers itch in the Lake of Garda
Bactofugation and the Bactotherm process
The effects of prefrontal lobotomy on aggressive behavior in dogs
Visual rating scales for screening whorl-stage corn for resistance to fall armyworm
Breakdown of seamounts at the trench axis, viewed from gravity anomaly
Kooken; pennsylvania's toughest cave
Recovery of new dinosaur and other fossils from the Early Cretaceous Arundel Clay facies (Potomac Group) of central Maryland, U.S.A
Zubor horny (Bison bonasus) v prirodnych podmienkach Slovensku
The extended Widal test in the diagnosis of fevers due to Salmonella infection
Hair of the american mastodon indicates an adaptation to a semi aquatic habitat

Anti-inflammatory activity of intravenous immunoglobulins protects against West Nile virus encephalitis


Anti-inflammatory activity of intravenous immunoglobulins protects against West Nile virus encephalitis



Journal of General Virology 96(Pt 6): 1347-1357



ISSN/ISBN: 0022-1317

PMID: 25667322

DOI: 10.1099/vir.0.000079

West Nile virus (WNV), an important global human pathogen, targets neurons to cause lethal encephalitis, primarily in elderly and immunocompromised patients. Currently, there are no approved therapeutic agents or vaccines to treat WNV encephalitis. Recent studies have suggested that inflammation is a major contributor to WNV encephalitis morbidity. In this study we evaluated the use of IVIG (intravenous immunoglobulins - a clinical product comprising pooled human IgG) as an anti-inflammatory treatment in a model of lethal WNV infection. We report here that IVIG and pooled human WNV convalescent sera (WNV-IVIG) inhibited development of lethal WNV encephalitis by suppressing central nervous system (CNS) infiltration by CD45(high) leukocytes. Pathogenic Ly6C(high) CD11b(+) monocytes were the major infiltrating subset in the CNS of infected control mice, whereas IVIG profoundly reduced infiltration of these pathogenic Ly6C(high) monocytes into the CNS of infected mice. Interestingly, WNV-IVIG was more efficacious than IVIG in controlling CNS inflammation when mice were challenged with a high-dose inoculum (10(5) versus 10(4) p.f.u.) of WNV. Importantly, adsorption of WNV E-glycoprotein neutralizing antibodies did not abrogate IVIG protection, consistent with virus neutralization not being essential for IVIG protection. These findings confirmed the potent immunomodulatory activity of generic IVIG, and emphasized its potential as an effective immunotherapeutic drug for encephalitis and other virus induced inflammatory diseases.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057207364

Download citation: RISBibTeXText

Related references

Live measles vaccine expressing the secreted form of the West Nile virus envelope glycoprotein protects against West Nile virus encephalitis. Journal of Infectious Diseases 191(2): 207-214, 2004

Orf Virus VIR Antagonizes p53-Mediated Antiviral Effects to Facilitate Viral Replication. Viral Immunology 33(6): 468-476, 2020

Dehydroepiandrosterone protects stressed mice from encephalitis by the attenuated west-nile virus. Stress and Health 8(3): 181-185, 1992

Treatment of West Nile virus encephalitis with intravenous immunoglobulin. Emerging Infectious Diseases 7(4): 759, 2001

Duplex microsphere-based immunoassay for detection of anti-West Nile virus and anti-St. Louis encephalitis virus immunoglobulin m antibodies. Clinical and Diagnostic Laboratory Immunology 12(5): 566-574, 2005

Validation of a microsphere-based immunoassay for detection of anti-West Nile virus and anti-St. Louis encephalitis virus immunoglobulin m antibodies. Clinical and Vaccine Immunology: Cvi 14(9): 1084-1093, 2007

Are ESR/CRP ratios helpful in differentiating West Nile encephalitis from non-West Nile virus meningitis/encephalitis?. Scandinavian Journal of Infectious Diseases 45(8): 652-654, 2013

The role for intravenous immunoglobulin in the treatment of West Nile virus encephalitis. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 37(6): E88-E90, 2003

Evaluation of a diagnostic algorithm using immunoglobulin M enzyme-linked immunosorbent assay to differentiate human West Nile Virus and St. Louis Encephalitis virus infections during the 2002 West Nile Virus epidemic in the United States. Clinical and Diagnostic Laboratory Immunology 11(6): 1130-1133, 2004

Recombinant canarypoxvirus vaccine carrying the prM/E genes of West Nile virus protects horses against a West Nile virus-mosquito challenge. Archives of Virology. Supplementum 2004(18): 221-230, 2004

West Nile virus encephalitis in a renal transplant recipient: the role of intravenous immunoglobulin. American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation 52(5): E19-E21, 2008

Evaluation of Electrolyte Concentration and Pro-Inflammatory and Oxidative Status in Dogs with Advanced Chronic Kidney Disease under Dietary Treatment. Toxins 12(1), 2019

Possible benefit of intravenous immunoglobulin therapy in a lung transplant recipient with West Nile virus encephalitis. Transplant Infectious Disease: An Official Journal of the Transplantation Society 4(3): 160-162, 2002

Review of West Nile virus epidemiology in Italy and report of a case of West Nile virus encephalitis. Journal of neurovirology 20(5): 437-441, 2014

Recombinant vesicular stomatitis virus-based west Nile vaccine elicits strong humoral and cellular immune responses and protects mice against lethal challenge with the virulent west Nile virus strain LSU-AR01. Vaccine 27(6): 893-903, 2009