+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Antibacterial activity on electrospun poly(lactide-co-glycolide) based membranes via Magainin II grafting

Antibacterial activity on electrospun poly(lactide-co-glycolide) based membranes via Magainin II grafting

Materials Science and Engineering. C Materials for Biological Applications 45: 510-518

An antimicrobial peptide (AMP), Magainin II (Mag II) was covalently immobilized on poly(lactide-co-glycolide) (PLGA) and PLGA/gelatin electrospun fibrous membranes. The surface immobilization was characterized by X-ray Photoelectron Spectroscopy (XPS). Scanning Electron Microscopy (SEM) and Atomic Force Microscopy studies showed that the surface morphology of the fibers at micron scale was not affected by the immobilization process. The antibacterial activity of the bound Mag II was tested against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. Bacterial adhesion tests, SEM and confocal analyses revealed that the attachment and survival of bacteria were inhibited on Mag II functionalized membranes. AMP immobilization strategy was introduced as a new perspective for the modulation of antibacterial properties on PLGA based materials prepared by electrospinning.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 057208944

Download citation: RISBibTeXText

PMID: 25491858

DOI: 10.1016/j.msec.2014.10.004

Related references

Prevention of postsurgery-induced abdominal adhesions by electrospun bioabsorbable nanofibrous poly(lactide-co-glycolide)-based membranes. Annals of Surgery 240(5): 910-915, 2004

Preparation and characterization of ibuprofen-loaded poly(lactide-co-glycolide)/poly(ethylene glycol)-g-chitosan electrospun membranes. Journal of Biomaterials Science. Polymer Edition 15(3): 279-296, 2004

Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranes. International Journal of Nanomedicine 9: 2373-2385, 2014

Distinctive degradation behaviors of electrospun polyglycolide, poly(DL-lactide-co-glycolide), and poly(L-lactide-co-epsilon-caprolactone) nanofibers cultured with/without porcine smooth muscle cells. Tissue Engineering. Part a 16(1): 283-298, 2010

Sustained antibacterial activity of doxycycline-loaded poly(D,L-lactide-co-glycolide) and poly(epsilon-caprolactone) nanoparticles. Nanomedicine 4(5): 519-530, 2009

Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. Journal of Controlled Release 98(1): 47-56, 2004

Complex sameness: Separation of mixed poly(lactide-co-glycolide)s based on the lactide:glycolide ratio. Journal of Controlled Release 300: 174-184, 2019

Evaluation of the antibacterial activity of poly-(d,l-lactide-co-glycolide) nanoparticles containing violacein. Journal of Nanoparticle Research 13(1): 355-363, 2011

Ciprofloxacin-encapsulated poly(DL-lactide-co-glycolide) nanoparticles and its antibacterial activity. International Journal of Pharmaceutics 352(1-2): 317-323, 2008

45S5Bioglass®-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity. Colloids and Surfaces. B Biointerfaces 132: 208-215, 2015

Effects of multiwalled carbon nanotubes on electrospun poly(lactide-co-glycolide)-based nanocomposite scaffolds on neural cells proliferation. Journal of Biomedical Materials Research. Part B Applied Biomaterials 105(5): 934-943, 2017

Construction of poly (vinyl alcohol)/poly (lactide-glycolide acid)/vancomycin nanoparticles on titanium for enhancing the surface self-antibacterial activity and cytocompatibility. Colloids and Surfaces. B Biointerfaces 151: 165-177, 2017

Amniotic epithelial stem cell biocompatibility for electrospun poly(lactide-co-glycolide), poly(ε-caprolactone), poly(lactic acid) scaffolds. Materials Science and Engineering. C Materials for Biological Applications 69: 321-329, 2016

Antibacterial Activity of Vancomycin Encapsulated in Poly(DL-lactide-co-glycolide) Nanoparticles Using Electrospraying. Probiotics and Antimicrobial Proteins 11(1): 310-316, 2019

Preparation of ciprofloxacin-encapsulated poly(DL-lactide-co-glycolide) microspheres and its antibacterial activity. Journal of Pharmaceutical Sciences 98(10): 3659-3665, 2009