+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Creating a graft-friendly environment for stem cells in diseased brains

Creating a graft-friendly environment for stem cells in diseased brains

Journal of Clinical Investigation 128(1): 116-119

Most of the adult CNS lacks regenerative activity in terms of both neuron birth and neurite outgrowth. While this regeneration-unfriendly environment of the adult CNS may preserve the existing neuronal circuitry that takes years to develop in higher organisms, it also poses a major obstacle for CNS repair later in life. In this issue of the JCI, Song et al. report on their development of a strategy that uses region-specific and molecularly engineered astrocytes to turn an unfavorable brain environment into a favorable one for engrafted neural stem/progenitor cells (NSC/NPCs). In a rat model of Parkinson's disease (PD), cografting NPCs with midbrain-derived astrocytes engineered to overexpress the transcription factors Nurr1 and Foxa2 promotes maturation and survival of the graft, resulting in therapeutic improvement. The results of this study raise the prospect of using modified astrocytes to improve the survival, maturation, and integration of engrafted NSC/NPCs as a restorative treatment for PD.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 057215092

Download citation: RISBibTeXText

PMID: 29227287

Related references

Creating a friendly working environment. 1978

Creating a friendly environment for your HIV medications. The effect of interactions. Positively Aware 16-21, 2005

Creating competitive advantage by using environment-friendly building processes. Building and Environment 36(3): 291-298, 2001

Creating a positive work environment: implementation of the nurse-friendly hospital criteria. Journal of Nursing Administration 39(2): 64-70, 2009

From databases to visualisation; providing a user friendly visual environment for creating 3D solid geology models. Publication Series - Australasian Institute of Mining and Metallurgy 4/95: 11-20, 1995

Knowing and connecting: competing demands and creating student-friendly and teacher-friendly nursing curricula. Journal of Nursing Education 42(9): 385-389, 2003

Age-Friendly Austin: Creating the Age-Friendly Action Plan. American Journal of Geriatric Psychiatry 25(3): S3-S4, 2017

Phagocytic Roles of Glial Cells in Healthy and Diseased Brains. Biomolecules and Therapeutics 26(4): 350-357, 2018

Meso-2,3-Dimercaptosuccinic acid partially restores phosphorus-32 8-azido-GTP-beta-tubulin interactions to both Alzheimers diseased brains and to HgEDTA treated control brains. FASEB Journal 7(3-4): A626, 1993

Stem cell research. Rat brains respond to embryonic stem cells. Science 295(5553): 254-255, 2002

Stem extension and subsequent flowering of seedlings grown under a film creating a far-red deficient environment. Scientia Horticulturae 96(1/4): 257-265, 2002

Keeping fattening pigs in an environment-friendly animal-friendly manner. KTBL Schrift ( 363): 148 pp., 1995

Glial cells as progenitors and stem cells: new roles in the healthy and diseased brain. Physiological Reviews 94(3): 709-737, 2014

Bone marrow-derived mesenchymal stem cells decrease acute graft-versus-host disease after allogeneic hematopoietic stem cells transplantation. Immunological Investigations 37(1): 29-42, 2008

Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease. Biology of Blood and Marrow Transplantation 16(6): 751-771, 2010