+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Association between inflammatory airway disease of horses and exposure to respiratory viruses: a case control study

Association between inflammatory airway disease of horses and exposure to respiratory viruses: a case control study

Multidisciplinary Respiratory Medicine 10(): 33-33

Inflammatory airway disease (IAD) in horses, similar to asthma in humans, is a common cause of chronic poor respiratory health and exercise intolerance due to airway inflammation and exaggerated airway constrictive responses. Human rhinovirus is an important trigger for the development of asthma; a similar role for viral respiratory disease in equine IAD has not been established yet. In a case-control study, horses with IAD (n = 24) were compared to control animals from comparable stabling environments (n = 14). Horses were classified using pulmonary function testing and bronchoalveolar lavage. PCR for equine rhinitis virus A and B (ERAV, ERBV), influenza virus (EIV), and herpesviruses 2, 4, and 5 (EHV-2, EHV-4, EHV-5) was performed on nasal swab, buffy coat from whole blood, and cells from BAL fluid (BALF), and serology were performed. Categorical variables were compared between IAD and control using Fisher's exact test; continuous variables were compared with an independent t-test. For all analyses, a value of P <0.05 was considered significant. There was a significant association between diagnosis of IAD and history of cough (P = 0.001) and exercise intolerance (P = 0.003) but not between nasal discharge and IAD. Horses with IAD were significantly more likely to have a positive titer to ERAV (68 %) vs. control horses (32 %). Horses with IAD had higher log-transformed titers to ERAV than did controls (2.28 ± 0.18 v.1.50 ± 0.25, P = 0.038). There was a significant association between nasal shedding (positive PCR) of EHV-2 and diagnosis of IAD (P = 0.002). IAD remains a persistent problem in the equine population and has strong similarities to the human disease, asthma, for which viral infection is an important trigger. The association between viral respiratory infection and development or exacerbation of IAD in this study suggests that viral infection may contribute to IAD susceptibility; there is, therefore, merit in further investigation into the relationship between respiratory virus exposure and development of IAD.

(PDF same-day service: $19.90)

Accession: 057250236

Download citation: RISBibTeXText

PMID: 26535117

DOI: 10.1186/s40248-015-0030-3

Related references

Association between respiratory viruses and exacerbation of COPD: a case-control study. Infectious Diseases 47(8): 523-529, 2016

The association of exposure to hepatitis B and C viruses with lung function and respiratory disease: a population based study from the NHANES III database. Respiratory Medicine 108(12): 1733-1740, 2015

Association between aflatoxin B1 occupational airway exposure and risk of hepatocellular carcinoma: a case-control study. Tumour Biology 35(10): 9577-9584, 2015

Respiratory mechanics in Standardbred horses with sub-clinical inflammatory airway disease and poor athletic performance. Veterinary Journal 173(1): 144-150, 2005

A metagenomics and case-control study to identify viruses associated with bovine respiratory disease. Journal of Virology 89(10): 5340-5349, 2015

Association between cough and cytology of bronchoalveolar lavage fluid and pulmonary function in horses diagnosed with inflammatory airway disease. Journal of Veterinary Internal Medicine 22(4): 1022-1028, 2008

Bayesian analysis of a matched case-control study with expert prior information on both the misclassification of exposure and the exposure-disease association. Statistics in Medicine 28(27): 3411-3423, 2010

Relationships between equine airway reactivity measured by flowmetric plethysmography and specific indicators of airway inflammation in horses with suspected inflammatory airway disease. Equine Veterinary Journal 48(4): 466-471, 2015

Exposure to biomass smoke and chronic airway disease in Mexican women. A case-control study. American Journal of Respiratory and Critical Care Medicine 154(3 Pt 1): 701-706, 1996

Inflammatory airway disease in horses from the police force a clinical study. Revista Brasileira De Ciencia Veterinaria: 2, 88-93, 2008

Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study. Thorax 58(1): 37-42, 2003

The association between inflammatory bowel disease and periodontitis among Jordanians: a case-control study. Journal of Periodontal Research 47(3): 293-298, 2012

Is there an association between prior anti-inflammatory drug exposure and occurrence of peritonsillar abscess (PTA)? A national multicenter prospective observational case-control study. European Journal of Clinical Microbiology & Infectious Diseases, 2016

Association Between Toxoplasma gondii Exposure and Heart Disease: A Case-Control Study. Journal of Clinical Medicine Research 8(5): 402-409, 2016

Lack of association of ACP1 gene with inflammatory bowel disease: a case-control study. Tissue Antigens 80(1): 61-64, 2012