+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Association between latent toxoplasmosis and clinical course of schizophrenia - continuous course of the disease is characteristic for Toxoplasma gondii-infected patients

Association between latent toxoplasmosis and clinical course of schizophrenia - continuous course of the disease is characteristic for Toxoplasma gondii-infected patients

Folia Parasitologica 62

The aim of the present study was to investigate the association between various clinical aspects of schizophrenia and seropositivity against Toxoplasma gondii (Nicolle et Manceaux, 1908). We selected 94 patients with schizophrenia and investigated the seropositivity rate for anti-T. gondii IgG antibodies by ELISA. Clinical parameters of schizophrenic patients such as illness type and status, clinical course, awareness of the illness and need for electroconvulsive therapy (ECT) were compared with their serological status. Anti-T. gondii IgG antibodies were detected in 43 (46%) of schizophrenic patients. Chronic patients had a rate of 34 (72%) seropositivity, whereas 9 (22%) of the patients with partial remission showed evidence of latent toxoplasmosis. Of continuous patients, 35 (81%) were found to be seropositive and this rate was significantly more than in the other groups. The rate of latent toxoplasmosis was detected significantly higher in patients who lack awareness of schizophrenia (36, i.e. 72%) than the patients who were aware of their illnesses (7, i.e. 16%). Anti-T. gondii IgG antibodies were detected in 38 (70%) of ECT performed patients while this percentage was 13% in the ones who had never been treated with ECT. This difference was also statistically significant. We showed that Toxoplasma-infected subjects had 15× higher probability of having continuous course of disease than Toxoplasma-free subjects. Our results put forth the possibility of latent toxoplasmosis to have a negative impact on the course of schizophrenia and treatment response of schizophrenic patients.

(PDF emailed within 1 workday: $29.90)

Accession: 057250349

Download citation: RISBibTeXText

PMID: 25960559

Related references

Toxoplasma gondii serology in HIV infected patients as a predictor of subsequent clinical toxoplasmosis. TENTH INTERNATIONAL CONFERENCE ON AIDS, INTERNATIONAL CONFERENCE ON STD [Author] Tenth International Conference on AIDS and the International Conference on STD, Vol 2; The global challenge of AIDS: Together for the future : 2) 155, 1994

Observation on the clinical and hemorrheological changes in schizophrenia patients infected with Toxoplasma gondii. China Tropical Medicine 6(3): 410-411, 2006

Incidence, immunological and clinical characteristics of reactivation of latent Toxoplasma gondii infection in HIV-infected patients. Epidemiology and Infection 143(3): 600-607, 2015

Evolving characteristics of toxoplasmosis in patients infected with human immunodeficiency virus-1: clinical course and Toxoplasma gondii-specific immune responses. Clinical Microbiology and Infection 13(5): 510-515, 2007

Comparison of genotypes of Toxoplasma gondii in domestic cats from Australia with latent infection or clinical toxoplasmosis. Veterinary Parasitology 228: 13-16, 2017

Inhibition of inducible nitric oxide synthase exacerbates chronic cerebral toxoplasmosis in Toxoplasma gondii-susceptible C57BL/6 mice but does not reactivate the latent disease in T. gondii-resistant BALB/c mice. Journal of Immunology 162(6): 3512-3518, 1999

Seroprevalence of toxoplasmosis in 346 HIV infected patients in the east of France. Serological follow-up study in patients not infected with Toxoplasma gondii. Presse Medicale 21(8): 394-395, 1992

Toxoplasma gondii infection and cerebral toxoplasmosis in HIV-infected patients. Future Microbiology 4(10): 1363-1379, 2010

Association between IgG subclasses against Toxoplasma gondii and clinical signs in newborns with congenital toxoplasmosis. Pediatric Infectious Disease Journal 32(1): 13-16, 2013

From latent disease to fatal disease in the white rat infected by Toxoplasma gondii and treated with synthetic steroids. Bulletin de la Societe de Pathologie Exotique et de Ses Filiales 55: 335-339, 1962

Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii Dopamine, a missing link between schizophrenia and toxoplasmosis?. Biological Psychology 63(3): 253-268, 2003

Predictive value of toxoplasma gondii IgG antibody titer on the occurrence of cerebral toxoplasmosis in HIV-infected patients. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 35(0): 211, 1995

Toxoplasma gondii surface antigen-1 in sera of HIV-infected patients as an indicator of reactivated toxoplasmosis. European Journal of Clinical Microbiology and Infectious Diseases 14(10): 899-903, 1995

The Effect of Latent Toxoplasma gondii Infection on the Immune Response in HIV-Infected Patients. Biomed Research International 2015: 271842, 2016

High predictive value of Toxoplasma gondii IgG antibody levels in HIV-infected patients for diagnosis of cerebral toxoplasmosis. European Journal of Clinical Microbiology and Infectious Diseases 15(11): 869-872, 1996