+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Association of Human Papillomavirus 31 DNA Load with Risk of Cervical Intraepithelial Neoplasia Grades 2 and 3



Association of Human Papillomavirus 31 DNA Load with Risk of Cervical Intraepithelial Neoplasia Grades 2 and 3



Journal of Clinical Microbiology 53(11): 3451-3457



The association between human papillomavirus 31 (HPV31) DNA loads and the risk of cervical intraepithelial neoplasia grades 2 and 3 (CIN2-3) was evaluated among women enrolled in the atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL) triage study (ALTS), who were monitored semiannually over 2 years and who had HPV31 infections detected at ≥1 visit. HPV31 DNA loads in the first HPV31-positive samples and in a random set of the last positive samples from women with ≥2 HPV31-positive visits were measured by a real-time PCR assay. CIN2-3 was histologically confirmed at the same time as the first detection of HPV31 for 88 (16.6%) of 530 women. After adjustment for HPV31 lineages, coinfection with other oncogenic types, and the timing of the first positive detection, the odds ratio (OR) per 1-log-unit increase in viral loads for the risk of a concurrent diagnosis of CIN2-3 was 1.5 (95% confidence interval [CI], 1.2 to 1.9). Of 373 women without CIN2-3 at the first positive visit who had ≥1 later visit, 44 had subsequent diagnoses of CIN2-3. The initial viral loads were associated with CIN2-3 diagnosed within 6 months after the first positive visit (adjusted OR, 1.5 [95% CI, 1.0 to 2.4]) but were unrelated to CIN2-3 diagnosed later. For a random set of 49 women who were tested for viral loads at the first and last positive visits, changes in viral loads were upward and downward among women with and without follow-up CIN2-3 diagnoses, respectively, although the difference was not statistically significant. Results suggest that HPV31 DNA load levels at the first positive visit signal a short-term but not long-term risk of CIN2-3.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057253335

Download citation: RISBibTeXText

PMID: 26292291

DOI: 10.1128/jcm.01279-15


Related references

Association of human papillomavirus type 31 variants with risk of cervical intraepithelial neoplasia grades 2-3. International Journal of Cancer 131(10): 2300-2307, 2012

Inverse association between methylation of human papillomavirus type 16 DNA and risk of cervical intraepithelial neoplasia grades 2 or 3. Plos one 6(8): E23897, 2011

Association between high-risk human papillomavirus DNA load and different histological grades of cervical neoplasia. Zhonghua Yu Fang Yi Xue Za Zhi 43(7): 565-570, 2009

Effect of cervical cytologic status on the association between human papillomavirus type 16 DNA load and the risk of cervical intraepithelial neoplasia grade 3. Journal of Infectious Diseases 198(3): 324-331, 2008

Human papillomavirus type 18 DNA load and 2-year cumulative diagnoses of cervical intraepithelial neoplasia grades 2-3. Journal of the National Cancer Institute 101(3): 153-161, 2009

Relationships between 80 human papillomavirus genotypes and different grades of cervical intraepithelial neoplasia: association and causality. Virology 283(1): 139-147, 2001

Association between human papillomavirus DNA load and development of cervical intraepithelial neoplasia and cervical cancer. International Journal of Gynecological Cancer 18(4): 755-760, 2007

Type-dependent association between risk of cervical intraepithelial neoplasia and viral load of oncogenic human papillomavirus types other than types 16 and 18. International Journal of Cancer 140(8): 1747-1756, 2017

The association between human papillomavirus 16, 18 DNA load and E6 protein expression in cervical intraepithelial neoplasia and cancer. Journal of Clinical Virology 108: 6, 2018

Short-term risk of cervical intraepithelial neoplasia grades 2 and 3 for women with normal cytology and human papillomavirus infection. Salud Publica de Mexico 52(6): 486-492, 2011

Correlations of high-risk human papillomaviral load to cervical intraepithelial neoplasia grades, expression of Ki-67 and P6ink4a and follow-up. Ai Zheng 27(5): 520-524, 2008

High-risk human papillomavirus load and biomarkers in cervical intraepithelial neoplasia and cancer. Apmis 122(5): 427-436, 2014

Long-term risk of cervical intraepithelial neoplasia grade 3 or worse according to high-risk human papillomavirus genotype and semi-quantitative viral load among 33,288 women with normal cervical cytology. International Journal of Cancer 137(1): 193-203, 2015

High-risk human papillomavirus DNA load in a population-based cervical screening cohort in relation to the detection of high-grade cervical intraepithelial neoplasia and cervical cancer. International Journal of Cancer 124(2): 381-386, 2009

Factors associated with an increased risk of prevalent and incident grade III cervical intraepithelial neoplasia and invasive cervical cancer among women with Papanicolaou tests classified as grades I or II cervical intraepithelial neoplasia. American Journal of Obstetrics & Gynecology 186(1): 28-34, 2002