+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Association of Myopic Optic Disc Deformation with Visual Field Defects in Paired Eyes with Open-Angle Glaucoma: A Cross-Sectional Study



Association of Myopic Optic Disc Deformation with Visual Field Defects in Paired Eyes with Open-Angle Glaucoma: A Cross-Sectional Study



Plos One 11(8): E0161961



To examine the association of myopia with the visual field (VF) defects in open-angle glaucoma (OAG) using paired eyes to eliminate the effect of unknown confounding factors that are diverse among individuals. One hundred eighteen eyes of 59 subjects with myopia (spherical equivalent [SE] ≥ -2 diopter [D] and axial length ≥ 24.0 mm) whose intra-ocular pressure between paired eyes was similar and the mean deviation (MD) of the Humphrey VF test differed by more than 6 dB were included. Refractive errors (SE, axial length) and parameters associated with the papillary and parapapillary myopic deformation (tilt ratio, torsion angle, and β-zone parapapillary atrophy [PPA] area without Bruch's membrane) were measured in each eye. The paired eyes were divided into worse and better eyes according to the MD of the VF, and parameters were compared between them. Further, multiple linear regression analysis was performed to examine the correlation of the difference in various parameters with the MD difference between paired eyes. The SE of all eyes was -6.39 ± 2.15 D (mean ± standard deviation) and axial length was 26.42 ± 1.07 mm. MD of the worse and better VF eyes were -13.56 ± 6.65 dB and -4.87 ± 5.32 dB, respectively. Eyes with worse VFs had significantly greater SE, axial length, tilt ratio, and PPA area without Bruch's membrane than those with better VFs (all P < 0.05). In multiple linear regression analysis, the difference of the MD between paired eyes was significantly correlated with the difference in the tilt ratio and PPA area without Bruch's membrane. The myopic papillary and parapapillary deformations, but not refractive error itself, were related to the worse VF in paired eyes with OAG. This suggests that myopia influences the severity of the glaucomatous VF defects via structural deformation.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057253742

Download citation: RISBibTeXText

PMID: 27571303

DOI: 10.1371/journal.pone.0161961


Related references

Association of Myopic Deformation of Optic Disc with Visual Field Progression in Paired Eyes with Open-Angle Glaucoma. Plos One 12(1): E0170733, 2017

The relationship between optic nerve head deformation and visual field defects in myopic eyes with primary open-angle glaucoma. Plos One 13(12): E0209755-E0209755, 2019

Association of Bruch's membrane opening and optic disc morphology to axial length and visual field defects in eyes with primary open-angle glaucoma. Graefe's Archive for Clinical and Experimental Ophthalmology 256(3): 599-610, 2018

Optic disc tilt direction affects regional visual field progression rates in myopic eyes with open-angle glaucoma. Graefe's Archive for Clinical and Experimental Ophthalmology 254(11): 2267-2276, 2016

The Optic Nerve Head in Primary Open-Angle Glaucoma Eyes With High Myopia: Characteristics and Association With Visual Field Defects. Journal of Glaucoma 25(6): E569-E575, 2017

Visual Field Progression Pattern Associated With Optic Disc Tilt Morphology in Myopic Open-Angle Glaucoma. American Journal of Ophthalmology 169: 33-45, 2017

Correlation between optic disc changes and visual field defects in chronic open-angle glaucoma. Transactions. Section on Ophthalmology. American Academy of Ophthalmology and Otolaryngology 81(2): 224-226, 1976

Bilateral visual field defects with optic disc drusen and secondary open angle glaucoma with PEX--clinical correlation with the HRA. Klinische Monatsblatter für Augenheilkunde 221(4): 280-284, 2004

Multiple Temporal Lamina Cribrosa Defects in Myopic Eyes with Glaucoma and Their Association with Visual Field Defects. Ophthalmology 124(11): 1600-1611, 2017

A study on correlation between the structural parameter of optic disc and visual field in primary open-angle glaucoma. Chinese Journal of Ophthalmology 36(4): 275-277, 2002

Comparison of optic nerve head topography and visual field in eyes with open-angle and angle-closure glaucoma. Ophthalmology 115(2): 239-245.E2, 2007

Influence of refraction on the visual field defects in normal tension glaucoma and primary open angle glaucoma eyes. Nippon Ganka Gakkai Zasshi 98(11): 1121-1125, 1994

Optic disc and visual field changes in primary open angle glaucoma. Australian Journal of Ophthalmology 9(3): 223-229, 1981

A comparative study of computerised visual field testing and optic disc morphometric parameters in the follow-up of primary open angle glaucoma. Eye 12: 916-920, 1999

Influence of myopic refraction on visual field defects in normal tension and primary open angle glaucoma. Japanese Journal of Ophthalmology 39(1): 60-64, 1995