EurekaMag
+ Translate
+ Most Popular
Identification of compounds with anti-West Nile Virus activity
Geological age of the Ptilophyllum flora; a critical reassessment
Nira (Co 86032) - a new variety of sugarcane for Maharashtra
Occurrence of Eutrichophilus mexicanus (Rudow, 1866) and Eutrichophilus lobatus (Ewing, 1936) (Phthiraptera: Trichodectidae) on Sphiggurus villosus (Cuvier, 1825) (Rodentia: Erethizontidae) in Rio de
An assessment of water quality of river ganga at garhmukteshwar ghaziabad uttar pradesh india
The identity of the lipstick mold of cultivated mushrooms agaricus bisporus
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
The composition of pampas-grass (Cortaderia argentea.)
Studies on feeding of tapioca thippi (tapioca or cassava starch waste) to swine
Effects of drum rolling on yield of summer groundnut
Integrated farming system for gardenland conditions of Coimbatore district - an over view
Influence of a decision analysis model on selection of drug therapy
Comparative performance of West Coast Tall and Lakshadweep Ordinary cultivars of coconut
Evaluation of WCT coconut and Komadan coconut
Cellars as hibernation sites for bats
Donkioporia expansa - A lesser known wood destroyer in buildings
The Bangla adaptation of Mini-Mental State Examination (BAMSE): An instrument to assess cognitive function in illiterate and literate individuals
Enterobacter amnigenus. An unusual human pathogen
'Rajeshwari' - a high-yielding white seeded variety of sesame for Andhra Pradesh
Gymnosperms of Sikkim, India
The great Coalinga cricket invasion
Psoriasis: correlation between severity index (PASI) and quality of life index (DLQI) in patients assessed before and after systemic treatment
Real-time PCR assays for the specific detection of monkeypox virus West African and Congo Basin strain DNA
Classification of fermented foods: worldwide review of household fermentation techniques
The biology of human starvation: some new insights

Bombyx mori E26 transformation-specific 2 (BmEts2), an Ets family protein, represses Bombyx mori Rels (BmRels)-mediated promoter activation of antimicrobial peptide genes in the silkworm Bombyx mori


Bombyx mori E26 transformation-specific 2 (BmEts2), an Ets family protein, represses Bombyx mori Rels (BmRels)-mediated promoter activation of antimicrobial peptide genes in the silkworm Bombyx mori



Insect Molecular Biology 25(5): 566-579



ISSN/ISBN: 0962-1075

PMID: 27227900

DOI: 10.1111/imb.12244

E26 transformation-specific (Ets) family transcription factors are known to play roles in various biological phenomena, including immunity, in vertebrates. However, the mechanisms by which Ets proteins contribute to immunity in invertebrates remain poorly understood. In this study, we identified a cDNA encoding BmEts2, which is a putative orthologue of Drosophila Yan and human translocation-ets-leukemia/Ets-variant gene 6, from the silkworm Bombyx mori. Expression of the BmEts2 gene was significantly increased in the fat bodies of silkworm larvae in response to injection with Escherichia coli and Staphylococcus aureus. BmEts2 overexpression dramatically repressed B. mori Rels (BmRels)-mediated promoter activation of antimicrobial peptide genes in silkworm cells. Conversely, gene knockdown of BmEts2 significantly enhanced BmRels activity. In addition, two κB sites located on the 5' upstream region of cecropin B1 were found to be involved in the repression of BmRels-mediated promoter activation. Protein-competition analysis further demonstrated that BmEts2 competitively inhibited binding of BmRels to κB sites. Overall, BmEts2 acts as a repressor of BmRels-mediated transactivation of antimicrobial protein genes by inhibiting the binding of BmRels to κB sites.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057316853

Download citation: RISBibTeXText

Related references

Cell-specific expression of enhanced green fluorescence protein under the control of neuropeptide gene promoters in the brain of the silkworm, Bombyx mori, using Bombyx mori nucleopolyhedrovirus-derived vectors. Insect Biochemistry and Molecular Biology 33(1): 7-12, 2003

Cell-specific expression of enhanced green fluorescence protein under the control of neuropeptide gene promoters in the brain of the silkworm, Bombyx mori, using Bombyx mori nucleopolyhedrovirus-derived vectors. Insect Biochemistry and Molecular Biology uary; 33(1): 7-12, 2003

Homologous region 3 from Bombyx mori nucleopolyhedrovirus enhancing the transcriptional activity of heat shock cognate 70-4 promoter from Bombyx mori and Bombyx mandarina in vitro and in vivo. Bioscience Biotechnology and Biochemistry 69(5): 1014-1017, 2005

Genome-wide identification, characterization of sugar transporter genes in the silkworm Bombyx mori and role in Bombyx mori nucleopolyhedrovirus (BmNPV) infection. Gene 579(2): 162-171, 2016

Characterization of an entomopathogenic fungi target integument protein, Bombyx mori single domain von Willebrand factor type C, in the silkworm, Bombyx mori. Insect Molecular Biology 26(3): 308-316, 2017

Susceptibility status of the silkworm (Bombyx mori) germplasm stocks in India to Bombyx mori nuclear polyhedrosis virus. Indian Journal of Sericulture 36(1): 51-54, 1997

Bombyx mori bidensovirus infection alters the intestinal microflora of fifth instar silkworm (Bombyx mori) larvae. Journal of Invertebrate Pathology 163: 48-63, 2019

Transgenic breeding of anti-Bombyx mori L nuclear polyhedrosis virus silkworm Bombyx mori. Acta Biochimica Et Biophysica Sinica: 10, 873-876, 2008

Transgenic breeding of anti-Bombyx mori L. nuclear polyhedrosis virus silkworm Bombyx mori. Acta Biochimica et Biophysica Sinica 40(10): 873-876, 2008

Screening of Promising Bivoltine hybrids of Mulberry Silkworm for their Susceptibility to Bombyx mori Nuclear Pplyhedrosis and Bombyx mori Infectious Flacherie Virus. International Journal of Industrial Entomology 12(2): 95-100, 2006

Arginine kinase is highly expressed in a resistant strain of silkworm (Bombyx mori, Lepidoptera): Implication of its role in resistance to Bombyx mori nucleopolyhedrovirus. Comparative Biochemistry and Physiology. Part B Biochemistry and Molecular Biology 158(3): 230-234, 2011

Chondroitinase from baculovirus Bombyx mori nucleopolyhedrovirus and chondroitin sulfate from silkworm Bombyx mori. Glycobiology 23(12): 1520-1530, 2013

Transcriptome analysis of the brain of the silkworm Bombyx mori infected with Bombyx mori nucleopolyhedrovirus: A new insight into the molecular mechanism of enhanced locomotor activity induced by viral infection. Journal of Invertebrate Pathology 128: 37-43, 2015

Caspase-1 from the silkworm, Bombyx mori, is involved in Bombyx mori nucleopolyhedrovirus infection. Zeitschrift für Naturforschung. C Journal of Biosciences 72(3-4): 147-153, 2017

Regulation of antimicrobial peptide genes via insulin-like signaling pathway in the silkworm Bombyx mori. Insect Biochemistry and Molecular Biology 103: 12-21, 2018