EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Brief review of the chicken Major Histocompatibility Complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance


Brief review of the chicken Major Histocompatibility Complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance



Poultry Science 95(2): 375-392



ISSN/ISBN: 0032-5791

PMID: 26740135

DOI: 10.3382/ps/pev379

Nearly all genes presently mapped to chicken chromosome 16 (GGA 16) have either a demonstrated role in immune responses or are considered to serve in immunity by reason of sequence homology with immune system genes defined in other species. The genes are best described in regional units. Among these, the best known is the polymorphic major histocompatibility complex-B (MHC-B) region containing genes for classical peptide antigen presentation. Nearby MHC-B is a small region containing two CD1 genes, which encode molecules known to bind lipid antigens and which will likely be found in chickens to present lipids to specialized T cells, as occurs with CD1 molecules in other species. Another region is the MHC-Y region, separated from MHC-B by an intervening region of tandem repeats. Like MHC-B, MHC-Y is polymorphic. It contains specialized class I and class II genes and c-type lectin-like genes. Yet another region, separated from MHC-Y by the single nucleolar organizing region (NOR) in the chicken genome, contains olfactory receptor genes and scavenger receptor genes, which are also thought to contribute to immunity. The structure, distribution, linkages and patterns of polymorphism in these regions, suggest GGA 16 evolves as a microchromosome devoted to immune defense. Many GGA 16 genes are polymorphic and polygenic. At the moment most disease associations are at the haplotype level. Roles of individual MHC genes in disease resistance are documented in only a very few instances. Provided suitable experimental stocks persist, the availability of increasingly detailed maps of GGA 16 genes combined with new means for detecting genetic variability will lead to investigations defining the contributions of individual loci and more applications for immunogenetics in breeding healthy poultry.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057327180

Download citation: RISBibTeXText

Related references

The chicken major histocompatibility complex in disease resistance and poultry breeding. Journal of Dairy Science 72(5): 1328-1333, 1989

The chicken major histocompatibility complex, its associations with immune responsiveness and disease resistance. Proceedings of the Australian Poultry Science Symposium 1989: 83-86, 1989

Susceptibility to murine lymphocytic choriomeningitis maps to class i major histocompatibility complex genes a model for major histocompatibility complex disease associations. Nature (London) 316(6031): 814-817, 1985

Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish. Cells 8(4), 2019

The chicken major histocompatibility complex: structure and impact on immune function, disease resistance and productivity. MHC, differentiation antigens, and cytokines in animals and birds: 7-26, 1990

Advance in association of major histocompatibility complex (MHC) gene polymorphisms with disease resistance characters in chicken. Journal of Agricultural Biotechnology 14(1): 122-127, 2006

The chicken major histocompatibility complex mhc in disease resistance and poultry breeding past present and future. Journal of Dairy Science 71(Suppl. 1): 202, 1988

Expression profiles of genes within a subregion of chicken major histocompatibility complex B in spleen after Marek's disease virus infection. Poultry Science 89(10): 2123-2129, 2010

The major histocompatibility complex la carte: are there analogies to plant disease resistance genes on the menu?. Plant Journal 2(1): 3-11, 1992

Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes. American Journal of Pathology 149(5): 1675-1683, 1996

A novel major histocompatibility complex -like system maps to chicken chromosome 1. Poultry Science 78(Suppl. 1): 38, 1999

Mapping genes to chicken microchromosome 16 and discovery of olfactory and scavenger receptor genes near the major histocompatibility complex. Journal of Heredity 105(2): 203-215, 2014

Resistance to Marek's disease is controlled by a gene within the B-F region of the chicken major histocompatibility complex in Rous sarcoma regressor or progressor inbred lines of chickens. Folia Biologica 30(4): 251-258, 1984

Major histocompatibility complex class II DNA polymorphisms in chicken strains selected for Marek's disease resistance and egg production or for egg production alone. Poultry Science 76(11): 1517-1523, 1997

Major histocompatibility complex class I is downregulated in Marek's disease virus infected chicken embryo fibroblasts and corrected by chicken interferon. Comparative Immunology Microbiology and Infectious Diseases 26(3): 189-198, 2003