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CD103+ γδ T cell large granular lymphocytosis in a patient with refractory celiac disease: a diagnostic enigma



CD103+ γδ T cell large granular lymphocytosis in a patient with refractory celiac disease: a diagnostic enigma



International Journal of Hematology 101(6): 603-607



Indolent γδ T cell lymphomas/leukemias are rare and overlap with the morphological spectrum of large granular lymphocyte (LGL) leukemia. We report an extremely rare case of CD103(+) γδ T LGL leukemia in a patient with celiac disease who presented with refractory diarrhea. Whether the refractory diarrhea in our patient was a manifestation of LGL leukemia itself or whether the clonal LGL expansion is a manifestation of refractory celiac disease (RCD) remains an enigma. This report highlights the diagnostic difficulties and the need of consensus in categorizing clonal CD103(+) lymphocytosis in patients with RCD.

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Accession: 057334782

Download citation: RISBibTeXText

PMID: 25637255

DOI: 10.1007/s12185-015-1736-x


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