Section 58
Chapter 57,376

Cetuximab in combination with cisplatin and 5-Fluorouracil induces dramatic response in metastatic refractory squamous cell carcinoma of the anal canal

Rogers, J.E.; Silva, N.N.; Eng, C.

Journal of Gastrointestinal Oncology 6(5): E82-E85


ISSN/ISBN: 2078-6891
PMID: 26487956
DOI: 10.3978/j.issn.2078-6891.2015.035
Accession: 057375503

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Metastatic squamous cell carcinoma (SCC) of the anal canal is rare with limited data regarding treatment. Epidermal growth factor receptor (EGFR) expression has been observed in SCC of the anal canal and Kristen rat sarcoma vial oncogene (KRAS) mutations are rare. EGFR monoclonal antibodies, cetuximab and panitumumab, represent a potential option in this patient population. We report a metastatic SCC of the anal canal patient treated with cetuximab in combination with cisplatin plus 5-Fluorouracil (5-FU) that had a dramatic response.

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