+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Changes in Prescription and Over-the-Counter Medication and Dietary Supplement Use Among Older Adults in the United States, 2005 vs 2011



Changes in Prescription and Over-the-Counter Medication and Dietary Supplement Use Among Older Adults in the United States, 2005 vs 2011



JAMA Internal Medicine 176(4): 473-482



Prescription and over-the-counter medicines and dietary supplements are commonly used, alone and together, among older adults. However, the effect of recent regulatory and market forces on these patterns is not known. To characterize changes in the prevalence of medication use, including concurrent use of prescription and over-the-counter medications and dietary supplements, and to quantify the frequency and types of potential major drug-drug interactions. Descriptive analyses of a longitudinal, nationally representative sample of community-dwelling older adults 62 to 85 years old. In-home interviews with direct medication inspection were conducted in 2005-2006 and again in 2010-2011. The dates of the analysis were March to November 2015. We defined medication use as the use of at least 1 prescription or over-the-counter medication or dietary supplement at least daily or weekly and defined concurrent use as the regular use of at least 2 medications. We used Micromedex to identify potential major drug-drug interactions. Population estimates of the prevalence of medication use (in aggregate and by therapeutic class), concurrent use, and major drug-drug interactions. The study cohort comprised 2351 participants in 2005-2006 and 2206 in 2010-2011. Their mean age was 70.9 years in 2005-2006 and 71.4 years in 2010-2011. Fifty-three percent of participants were female in 2005-2006, and 51.6% were female in 2010-2011. The use of at least 1 prescription medication slightly increased from 84.1% in 2005-2006 to 87.7% in 2010-2011 (P = .003). Concurrent use of at least 5 prescription medications increased from 30.6% to 35.8% (P = .02). While the use of over-the-counter medications declined from 44.4% to 37.9%, the use of dietary supplements increased from 51.8% to 63.7% (P < .001 for both). There were clinically significant increases in the use of statins (33.8% to 46.2%), antiplatelets (32.8% to 43.0%), and omega-3 fish oils (4.7% to 18.6%) (P < .05 for all). In 2010-2011, approximately 15.1% of older adults were at risk for a potential major drug-drug interaction compared with an estimated 8.4% in 2005-2006 (P < .001). Most of these interacting regimens involved medications and dietary supplements increasingly used in 2010-2011. In this study, the use of prescription medications and dietary supplements, and concurrent use of interacting medications, has increased since 2005, with 15% of older adults potentially at risk for a major drug-drug interaction. Improving safety with the use of multiple medications has the potential to reduce preventable adverse drug events associated with medications commonly used among older adults.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057378824

Download citation: RISBibTeXText

PMID: 26998708

DOI: 10.1001/jamainternmed.2015.8581


Related references

Changes in the Use of Prescription and Over-the-Counter Medications and Dietary Supplements in the United States: 2005 Versus 2011. Value in Health 19(3): A58-A59, 2016

Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States. JAMA 300(24): 2867-2878, 2008

Dietary Supplement Use Was Very High among Older Adults in the United States in 2011-2014. Journal of Nutrition 147(10): 1968-1976, 2017

Prescription medication use among normal weight, overweight, and obese adults, United States, 2005-2008. Annals of Epidemiology 22(2): 112-119, 2012

Over the Counter Medication and Dietary Supplements Use Among Older Adults. Value in Health 17(7): A506, 2014

National estimates and predictors of prescription medication sample use in the United States, 1999-2005. Journal of the American Pharmacists Association 50(6): 677-685, 2011

Prescription sleep aid use among adults: United States, 2005-2010. Nchs Data Brief 2014(127): 1-8, 2014

Concomitant dietary supplement and prescription medication use is prevalent among US adults with doctor-informed medical conditions. Journal of the Academy of Nutrition and Dietetics 114(11): 1784-90.E2, 2014

Barriers to antihypertensive medication adherence among adults--United States, 2005. Journal of Clinical Hypertension 10(12): 922-929, 2008

Prescription Medication Use Among Normal Weight, Overweight, and Obese Adults, United States, 25–28. 2012

Self-reported hypertension and use of antihypertensive medication among adults - United States, 2005-2009. Mmwr. Morbidity and Mortality Weekly Report 62(13): 237-244, 2013

Prescription cholesterol-lowering medication use in adults aged 40 and over: United States, 2003-2012. Nchs Data Brief 2015(177): 1-8, 2015

Prevalence of Cholesterol Treatment Eligibility and Medication Use Among Adults--United States, 2005-2012. Mmwr. Morbidity and Mortality Weekly Report 64(47): 1305-1311, 2016

Prescription and Nonprescription Sleep Product Use Among Older Adults in the United States. American Journal of Geriatric Psychiatry 27(1): 32-41, 2019

Sources of Prescription Medication Misuse Among Young Adults in the United States: The Role of Educational Status. Journal of Clinical Psychiatry 79(2):, 2018