+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Chemoprophylactic and therapeutic efficacy of thymol in murine cystic echinococcosis



Chemoprophylactic and therapeutic efficacy of thymol in murine cystic echinococcosis



Parasitology International 64(5): 435-440



Cystic echinococcosis is a zoonotic disease caused by the larval stage of the cestode Echinococcus granulosus. The drugs commonly used against cystic echinococcosis are benzimidazoles. Unfortunately, 20%-40% of cases do not respond favorably to such chemotherapy. Consequently, the search of new therapeutic alternatives such as the use of traditional medicinal plants has been increased. The aim of the current experimental work was to investigate the chemoprophylactic and clinical efficacy of thymol on mice infected with E. granulosus metacestodes. Thymol (40 mg/kg) was administered under two different therapeutic schemes: dosing every 24h over 20 days and treatment every 12h for 10 days. Thymol demonstrated efficacy against experimental murine cystic echinococcosis. The chemoprophylactic and therapeutic effects of thymol were comparable to that of albendazole. Due to the lack of toxicity observed in mice at the tested doses; we consider that thymol is a potential alternative to be applied for the treatment of human hydatid disease.

(PDF emailed within 0-6 h: $19.90)

Accession: 057395808

Download citation: RISBibTeXText

PMID: 26096310

DOI: 10.1016/j.parint.2015.06.005


Related references

Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis. Veterinary Parasitology 203(1-2): 80-86, 2014

Chemoprophylactic activity of flubendazole in cystic echinococcosis. ChemoTherapy 56(5): 386-392, 2011

Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis. Plos Neglected Tropical Diseases 11(2): E0005370, 2017

Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice. Veterinary Parasitology 251: 78-84, 2018

Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice. Veterinary Parasitology 251: 78-84, 2018

B-ultrasonic diagnosis of hepatic cystic echinococcosis complicated by cystic echinococcosis in other organs. Endemic Diseases Bulletin 9(3): 60-61, 1994

Overview of therapeutic options for cystic echinococcosis. Parassitologia 46(1-2): 53-55, 2004

Reappraisal of mebendazole (Vermox) efficacy for treatment of cystic echinococcosis. Endemic Diseases Bulletin 15(2): 69-72, 82, 2000

Efficacy of ablendazole emulsion in treatment of 212 patients with cystic echinococcosis. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 19(3): 129-134, 2003

Efficacy of albendazole emulsion in treatment of 212 patients with cystic echinococcosis. Chinese Journal of Parasitology and Parasitic Diseases 19(3): 129-134, 2001

Enhancement of the Therapeutic Effect of Albendazole on Cystic Echinococcosis using a Herbal Product. Journal of Investigative Surgery 2017: 1-8, 2017

Evaluation of criterion for assessing the efficacy in pharmacotherapy of liver cystic echinococcosis. Chinese Journal of Parasitic Disease Control 15(3): 161-165, 2002

Efficacy of radiotherapy for the treatment of cystic echinococcosis in naturally infected sheep. Infectious Diseases of Poverty 6(1): 88, 2017

Chemotherapy of human cystic echinococcosis: comparative efficacy of mebendazole and albendazole. Annals of Tropical Medicine and Parasitology 86(1): 59-66, 1992

Human cystic echinococcosis: epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects. Asian Pacific Journal of Tropical Medicine 5(4): 253-260, 2012