+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Chronic heart failure and aging - effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study



Chronic heart failure and aging - effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study



European Journal of Preventive Cardiology 23(4): 349-358



A reduction in number and function of endothelial progenitor cells (EPCs) occurs in both physiologic aging and chronic heart failure (CHF). We assessed whether disease and aging have additive effects on EPCs or whether beneficial effects of exercise training are diminished in old age. We randomized 60 patients with stable CHF and 60 referent controls to a training or a control group. To detect possible aging effects we included subjects below 55 (young) and above 65 years (older). Subjects in the training group exercised four times daily at 60% to 70% of VO2max for four weeks under supervision. At baseline and after the intervention the number and function of EPCs were assessed. As compared with young referent controls, older referent controls showed at baseline a reduced EPC number (young: 190 ± 37 CD34/KDR positive cells/ml blood; older: 131 ± 26 CD34/KDR positive cells/ml blood; p < 0.05) and function (young: 230 ± 41 migrated cells/1000 plated cells; older: 185 ± 28 cells/1000 plated cells; p < 0.05). In young and older CHF patients EPC-number (young: 85 ± 21 CD34/KDR positive cells/ml blood; older: 78 ± 20 CD34/KDR positive cells/ml blood) and EPC-function (young: 113 ± 26 cells/1000 plated cells; older: 120 ± 27 cells/1000 plated cells) were impaired. As a result of exercise training, EPC function improved by 24% in older referent controls (p < 0.05), while it remained unchanged in young training referent controls and controls respectively. In young and older patients with CHF four weeks of exercise training resulted in a significant improvement in EPC numbers and EPC function (young: number +66% function +43%; p < 0.05; older: number +69% function +36%; p < 0.05). These results were accompanied by a significant increase in flow mediated dilatation in the training groups of young/older CHF patients and in older referent controls. Four weeks of exercise training are effective in improving EPC number and EPC function in CHF patients. These training effects were not impaired among older patients, emphasizing the potentials of rehabilitation interventions in a patient group where CHF has a high prevalence.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057405979

Download citation: RISBibTeXText

PMID: 26015451

DOI: 10.1177/2047487315588391


Related references

Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study. European Heart Journal 33(14): 1758-1768, 2012

Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study. Circulation 125(22): 2716-2727, 2012

Improved left ventricular function and reduced peripheral resistance after long-term exercise training in patients with chronic heart failure The Leipzig Heart Failure Training Trial. Journal of the American College of Cardiology 35(2 Suppl A): 231A, 2000

Antiremodeling effect of long-term exercise training in patients with stable chronic heart failure: Results of the exercise in left ventricular dysfunction and chronic heart failure (ELVD-CHF) trial. Circulation 108(5): 554-559, 2003

Long-term exercise training in chronic heart failure Preliminary results of the exercise in left ventricular dysfunction and chronic heart failure trial. Circulation 94(8 Suppl. ): I179, 1996

Safety and effects of physical training in chronic heart failure. Results of the Chronic Heart Failure and Graded Exercise study (CHANGE). European Heart Journal 20(12): 872-879, 1999

Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial. European Journal of Cardiovascular Prevention and Rehabilitation 10(5): 336-344, 2003

Effects of exercise training on endothelial progenitor cells in patients with chronic heart failure. Journal of Cardiac Failure 13(9): 701-708, 2007

Exercise training in patients with chronic heart failure improves endothelial function predominantly in the trained extremities. Circulation Journal 67(6): 505-510, 2003

Endothelial dysfunction in patients with chronic heart failure: Systemic effects of lower-limb exercise training. Journal of the American College of Cardiology 37(2): 392-397, 2001

Additional effect of dietary supplementation with L-arginine to exercise training on improving endothelial function in patients with chronic heart failure. Circulation 98(17 Suppl. ): I318, Oct 27, 1998

Additional effect of dietary supplementation with L-arginine to exercise training on restoring endothelial function in patients with chronic heart failure. European Heart Journal 19(ABST Suppl. ): 226, 1998

Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. Journal of the American College of Cardiology 35(3): 706-713, 2000

Exercise training in chronic heart failure Effects on markers of endothelial damage, inflammatory cytokine activation, and peripheral hypoxia. Circulation 102(18 Suppl.): II 678, October 31, 2000

Exercise training and losartan improve endothelial function in heart failure rats by different mechanisms. Scandinavian Cardiovascular Journal 47(3): 160-167, 2014