+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Clinical and light microscopic studies of the conjunctival tissues of dogs with bilateral keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine



Clinical and light microscopic studies of the conjunctival tissues of dogs with bilateral keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine



Biotechnic and Histochemistry 90(3): 223-230



We determined the concentrations of goblet and immune cells in conjunctival imprints and tissues of canines with keratoconjunctivitis sicca (KCS) before and after cyclosporine A (CsA) treatment. Twelve dogs with bilateral KCS were assigned to three groups: untreated, treatment group 1, and treatment group 2. The treatment groups were treated topically with 2% ophthalmic CsA solution for 45 days; CsA treatment group 2 was followed for an additional 30 days after discontinuation of the drug. Schirmer tear test (STT) scores were recorded prior to CsA treatment and on alternate days throughout the experiment. CsA treatment improved the STT scores, restored conjunctival histology, increased goblet and epithelial cell numbers, and decreased numbers of inflammatory cells. Although the STT scores regressed slightly at day 30 after discontinuing the treatment, the scores were higher than the baseline values. Topical CsA treatment resolved clinical signs of KCS, improved STT scores and restored normal conjunctival histology.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057419357

Download citation: RISBibTeXText

PMID: 25747049

DOI: 10.3109/10520295.2014.930177


Related references

Conjunctival impression cytology from dogs with keratoconjunctivitis sicca. Pre- and post-treatment with topical cyclosporine. Advances in Experimental Medicine and Biology 438: 997, 1998

Clinical evaluation of 1% cyclosporine for topical treatment of keratoconjunctivitis sicca in dogs. Journal of the American Veterinary Medical Association 199(8): 1039-1042, 1991

Keratoconjunctivitis sicca in dogs: Treatment with topical cyclosporine. Veterinary medicine reportng 2(2): 115-127, 1990

Topical administration of cyclosporine for treatment of keratoconjunctivitis sicca in dogs. Journal of the American Veterinary Medical Association 199(8): 1043-1046, 1991

Cellular immunity in dogs with keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine. Veterinary Immunology and Immunopathology 49(3): 199-208, 1995

Cellular immunity in dogs with keratoconjunctivitis sicca before and after treatment with topical 2 percent cyclosporine. Veterinary Immunology & Immunopathology 49(3): 199-208, 1995

Topical administration of petrolatum based cyclosporine for treatment of keratoconjunctivitis sicca in dogs. Journal of Veterinary Clinics 19(2): 260-263, 2002

Microorganisms isolated from the corneal surface before and during topical cyclosporine treatment in dogs with keratoconjunctivitis sicca. American Journal of Veterinary Research 56(7): 880-884, 1995

Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca. Cornea 24(1): 80-85, 2005

Topical Cyclosporine Inhibits Conjunctival Epithelial Apoptosis in Experimental Murine Keratoconjunctivitis Sicca. Cornea 24(1): 80-85, 2005

Topical cyclosporine therapy for keratoconjunctivitis sicca in dogs. Cornell Veterinarian 79(3): 207-209, 1989

Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2% cyclosporine for treatment of dogs with keratoconjunctivitis sicca. American Journal of Veterinary Research 63(5): 688-694, 2002

Topical application of cyclosporine in the management of keratoconjunctivitis sicca in dogs. Journal of the American Animal Hospital Association 26(3): 269-274, 1990

Treatment of keratoconjunctivitis sicca in dogs with cyclosporine ophthalmic ointment: a European clinical field trial. Veterinary Record 137(20): 504-507, 1995

Topical cyclosporine A 0.05% in the treatment of keratoconjunctivitis sicca. Klinische Monatsblatter für Augenheilkunde 229(5): 548-553, 2012