EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Clinical and molecular characteristics of bloodstream infections caused by Candida albicans in children from 2003 to 2011


Clinical and molecular characteristics of bloodstream infections caused by Candida albicans in children from 2003 to 2011



Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases 21(11): 1018.e1-8



ISSN/ISBN: 1198-743X

PMID: 26148466

DOI: 10.1016/j.cmi.2015.06.024

We investigated the clinical and molecular characteristics of Candida albicans bloodstream infection (BSI) in children from a tertiary-level medical centre in Taiwan over a 9-year period from January 2003 to December 2011. We performed multilocus sequence typing (MLST) to investigate the genetic relatedness of these C. albicans BSI isolates. A total of 79 episodes of C. albicans BSI in 76 paediatric patients were identified, including 41 (51.9%) from the paediatric intensive care unit, 24 (30.4%) from the neonatal intensive care unit and 14 (17.7%) from general wards. More than half (59.5%) of these patients had underlying chronic co-morbidities, and the majority (94.9%) had a catheter or some other artificial device. All the isolates were susceptible to the antifungal agents tested. Only 32.9% (26/79) received effective antifungal agents within 24 h of onset of candidaemia. Twenty-five (31.6%) patients had persistent candidaemia (>3 days after the start of antifungal treatment) and candidaemia-attributable mortality rate was 22.8% (18/79). The 72 isolates available for MLST yielded 53 unique diploid sequence types (DSTs). Forty-five DSTs were singletons and eight DSTs were shared by 27 (37.5%) isolates. Seventy-one (98.6%) isolates were clustered within previously known clades. Based on the definition of two or more strains with shared DST occurring within a period of 90 days, 10.1% of the infections were categorized as nosocomial clusters, most commonly identified in the intensive care units. Although cluster-associated candidaemia was not associated with a higher mortality rate, none of the clusters were identified by the hospital infection control team.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057419429

Download citation: RISBibTeXText

Related references

Clinical characteristics, risk factors and outcomes of mixed Candida albicans/bacterial bloodstream infections. Bmc Infectious Diseases 20(1): 810, 2020

Epidemiology, risk factors, treatment and outcome of Candida bloodstream infections because of Candida albicans and Candida non-albicans in two district general hospitals in the United Kingdom. International Journal of Clinical Practice 2020: e13655, 2020

Bloodstream Infections With Candida auris Among Children in Colombia: Clinical Characteristics and Outcomes of 34 Cases. Journal of the Pediatric Infectious Diseases Society 2020, 2020

Phenotypic and genotypic characteristics of Candida albicans isolates from bloodstream and mucosal infections. Mycoses 60(8): 534-545, 2017

Comparison of the clinical risk factors between Candida albicans and Candida non-albicans species for bloodstream infection. Journal of Antibiotics 67(4): 311-314, 2014

Candida albicans versus non-albicans bloodstream infections: the comparison of risk factors and outcome. Journal of Microbiology Immunology and Infection 44(5): 369-375, 2011

Candida albicans and non-albicans bloodstream infections in adult and pediatric patients: comparison of mortality and costs. Pediatric Infectious Disease Journal 28(5): 433-435, 2009

Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections. American Journal of Infection Control 38(1): 78-80, 2010

Candida albicans versus non-albicans intensive care unit-acquired bloodstream infections: differences in risk factors and outcome. Anesthesia and Analgesia 106(2): 523-9 Table of Contents, 2008

Frequency and clinical significance of bloodstream infections caused by C albicans strains with reduced susceptibility to fluconazole. Diagnostic Microbiology and Infectious Disease 44(2): 163-167, 2002

Comparison of E,E-Farnesol Secretion and the Clinical Characteristics of Candida albicans Bloodstream Isolates from Different Multilocus Sequence Typing Clades. Plos one 11(2): E0148400, 2016

Inflammatory response and clinical course of adult patients with nosocomial bloodstream infections caused by Candida spp. Clinical Microbiology and Infection: the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 12(2): 170-177, 2006

Factors and outcomes associated with candidemia caused by non-albicans Candida spp versus Candida albicans in children. American Journal of Infection Control 46(12): 1387-1393, 2018

Evaluation of the effectiveness of natamycin in the treatment of diabetic children with infections caused by candida albicans. Current Therapeutic Research 40(6): 1029-1033, 1986

Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters. Pathogens 4(3): 457-469, 2015