EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Compact multi-channel surface plasmon resonance sensor for real-time multi-analyte biosensing



Compact multi-channel surface plasmon resonance sensor for real-time multi-analyte biosensing



Optics Express 23(16): 20540-8



A compact multi-channel surface plasmon resonance (SPR) biosensor is demonstrated based on a tablet as the measurement platform. The SPR biosensor employs a bundle of fiber-optic SPR sensors as the multiplexed sensing elements that are illuminated by a light-emitting diode (LED) plane light source and detected by a cordless camera. The multi-channel SPR biosensor was based on optical fiber components for precise, label-free and high-throughput detection without the use of complex, specialized or fragile instrumentation that would require optical calibration. The reference and control channels compensated for the fluctuation of the LED light source and the bulk refractive index, increasing the accuracy and reliability of the biosensor. The multi-channel SPR biosensor was applied for multi-analyte biosensing of immunoglobulin G (IgG) and concanavalin A (Con A). The channels functionalized with staphylococcal protein A (SPA) and ribonuclease B (RNase B) only showed relative intensity responses to their corresponding analytes. Moreover, the multi-channel SPR sensors responded to the specific detection of IgG and Con A with an approximately linear relative intensity response to the analyte concentration. Hence, multiple analytes were simultaneously and quantitatively detected with the multi-channel SPR biosensor. This compact, cost-effective multi-channel SPR biosensor is adapted for point-of-care tests, which are important in healthcare and environmental monitoring and for biomolecular interaction analysis.

(PDF emailed within 0-6 h: $19.90)

Accession: 057454183

Download citation: RISBibTeXText

PMID: 26367906

DOI: 10.1364/OE.23.020540



Related references

Multi-analyte surface plasmon resonance biosensing. Methods 37(1): 26-36, 2005

Novel concept of multi-channel fiber optic surface plasmon resonance sensor. Sensors and Actuators B: Chemical 139(1): 199-203, 2009

Single- and multi-analyte determination of gonadotropic hormones in urine by Surface Plasmon Resonance immunoassay. Analytica Chimica Acta 647(2): 202-209, 2009

Single and multi-analyte surface plasmon resonance assays for simultaneous detection of cholinesterase inhibiting pesticides. Sensors and Actuators B: Chemical 118(1-2): 399-407, 2006

Reference-compensated biosensing using a dual-channel surface plasmon resonance sensor system based on a planar lightpipe configuration. Sensors and Actuators B: Chemical 51(1-3): 38-45, 1998

Development of a Portable Surface Plasmon Resonance Sensor with Multi-Sensing Points Based on the Linear CCD Sensor. Analytical Sciences 32(6): 673-679, 2016

Compact 5-LEDs illumination system for multi-spectral surface plasmon resonance sensing. Sensors and Actuators B: Chemical 209: 208-211, 2015

Overview of the Alaskan experience with multi-scale, multi-project, multi-sensor real-time geophysical data processing. Seismological Research Letters 71(2): 233, 2000

High-performance compact SPR sensor for multi-analyte sensing. Sensors and Actuators B: Chemical 148(2): 544-549, 2010

Estimation of analyte concentration by surface plasmon resonance-based biosensing using parameter identification techniques. Analytical Biochemistry 419(2): 140-144, 2012

Real-time label-free surface plasmon resonance biosensing with gold nanohole arrays fabricated by nanoimprint lithography. Sensors 13(10): 13960-8, 2014

A multi-purpose sensor based on surface plasmon polariton resonance in a Schottky structure. Sensors and Actuators A, Physical 42(1-3): 547-552, 1994

A compact multi-channel apparatus for automated real-time monitoring of bioluminescence. Journal of Biochemical and Biophysical Methods 70(4): 535-538, 2007

Multi-sensor technique and solid-state electrochemical sensor system for real-time and dynamic monitoring of multi-component gases. Sensors and Actuators B: Chemical 108(1-2): 379-383, 2005

Design and fabrication of an alternating dielectric multi-layer device for surface plasmon resonance sensor. Sensors and Actuators B: Chemical 113(1): 169-176, 2006