+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparative study of radiographic and laboratory findings between Beta thalassemia major and Beta thalassemia intermedia patients with and without treatment by hydroxyurea



Comparative study of radiographic and laboratory findings between Beta thalassemia major and Beta thalassemia intermedia patients with and without treatment by hydroxyurea



Iranian Red Crescent Medical Journal 17(2): E23607



In patients with thalassemia, chronic anemia causes bone marrow expansion and consequently skeletal manifestation in spine, skull, face and rib bones. We aimed to compare chest radiographic findings and facial bone deformity in patients with thalassemia major (TM) and intermedia. In this cross sectional study, 86 consecutive thalassemia patients referring to the Thalassemia clinic in Shiraz, Southern Iran were evaluated during 2012. Patients were divided into three groups including TM and thalassemia intermedia (TI) with and without taking hydroxyurea (HU). Findings ofchest radiography (trabeculation, rib widening and paraspinal masses) as well as facial bone deformity were evaluated by an expert radiologist. Besides, laboratory findings were measured regarding hemoglobin, ferritin, NRBC and platelet count. All radiologic findings were significantly higher in patients with TI compared to TM (P< 0.05). In patients with TI, only trabeculation was observed with a higher frequency in patients with HU compared to those without HU (68% vs. 27.3%, P= 0.008). In the regression model, from all variables evaluated, only NRBC showed a significant correlation with trabeculation (Exp B = 1.014, CI: 1.004-1.025, P = 0.008) and age showed a significant correlation with paravertebral mass (Exp B = 1.147, CI: 1.03-1.27, P = 0.013). In patients with TM, bone widening, trabeculation, paraspinal masses and facial bone deformity were lower than patients with TI, whichcan be related to effectiveness of therapy with blood transfusion irrespective of its adverse effects in TM patients.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 057459398

Download citation: RISBibTeXText

PMID: 25838937


Related references

Echocardiographic finding in beta-thalassemia intermedia and major: absence of pulmonary hypertension following hydroxyurea treatment in beta-thalassemia intermedia. European Journal of Haematology 82(3): 213-218, 2009

A comparison of heart function and arrhythmia in clinically asymptomatic patients with beta thalassemia intermedia and beta thalassemia major. Hematology 22(1): 25-29, 2017

Cerebral Artery Velocity Determined by Transcranial Doppler Ultrasonography in Patients With beta-Thalassemia Intermedia Compared to beta-Thalassemia Major. 2013

Malignancies in patients with beta-thalassemia major and beta-thalassemia intermedia: a multicenter study in Iran. Pediatric Blood and Cancer 53(6): 1064-1067, 2009

Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation. PhytoTherapy Research 24(9): 1334-1338, 2010

Comparative study of hypogonadism in beta-thalassemia intermedia patients with and without hydroxyurea. Hematology 17(2): 122-124, 2012

A rare thalassemia intermedia case caused by co-existence of Hb H disease (--(SEA)/-alpha(4.2)) and beta-thalassemia major (beta (CD17A)>T/beta (IVS2-654C)>T): implications for prenatal diagnosis. Nan Fang Yi Ke Da Xue Xue Bao 28(1): 16-19, 2008

Comparative evaluation of renal findings in Beta-thalassemia major and intermedia. Saudi Journal of Kidney Diseases and Transplantation 19(2): 206-209, 2008

Two thalassemia intermedia patients with delta beta/beta-thalassemia and a deletional type alpha-thalassemia. Haematologica 86(1): 108-108, 2001

Effect of alpha-gene numbers on the expression of beta-thalassemia intermedia, beta-thalassemia and (delta beta)0-thalassemia traits. Human Heredity 48(3): 121-125, 1998

mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models. American Journal of Hematology 81(7): 479-483, 2006

Molecular characterization of beta-thalassemia major and beta-thalassemia intermedia in China and Southeast Asia. Progress in Clinical and Biological Research 251: 401-412, 1987

The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran. Epidemiology and Health 40: E2018048, 2018

Long-term hydroxyurea therapy in thalassemia intermedia and thalassemia major patients. Blood 92(10 Suppl. 1 Part 1-2): 36B, 1998

Switch from beta-thalassemia major to beta-thalassemia intermedia after secondary graft failure. Experimental and Clinical Transplantation 8(3): 269-271, 2010