+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection



Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection



Euro Surveillance 20(41):



Plaque reduction neutralisation tests (PRNT), microneutralisation (MN), Middle East respiratory syndrome (MERS)-spike pseudoparticle neutralisation (ppNT) and MERS S1-enzyme-linked immunosorbent assay (ELISA) antibody titres were compared using 95 sera from 17 patients with MERS, collected two to 46 days after symptom onset. Neutralisation tests correlated well with each other and moderately well with S1 ELISA. Moreover to compare antigenic similarity of genetically diverse MERS-CoV clades, the response of four sera from two patients sampled at two time periods during the course of illness were tested by 90% PRNT. Genetically diverse MERS-CoV clades were antigenically homogenous.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 057470778

Download citation: RISBibTeXText

PMID: 26538277


Related references

Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection. Journal of Infectious Diseases 213(10): 1557-1561, 2016

Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity. Clinical Microbiology and Infection 22(10): 880-886, 2016

Middle East respiratory syndrome coronavirus (MERS-CoV) infection. British Journal of Hospital Medicine 78(1): 23-26, 2017

Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings. Ajr. American Journal of Roentgenology 203(4): 782-787, 2014

First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities - May 2014. Mmwr. Morbidity and Mortality Weekly Report 63(19): 431-436, 2014

Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America 110(41): 16598-16603, 2013

Global seasonal occurrence of middle east respiratory syndrome coronavirus (MERS-CoV) infection. European Review for Medical and Pharmacological Sciences 22(12): 3913-3918, 2018

Infection prevention and control guidelines for patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. Saudi Medical Journal 35(8): 897-913, 2014

Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4--The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS). Bioorganic and Medicinal Chemistry 23(17): 6036-6048, 2015

Real-time sequence-validated loop-mediated isothermal amplification assays for detection of Middle East respiratory syndrome coronavirus (MERS-CoV). Plos one 10(4): E0123126, 2015

Middle East respiratory syndrome coronavirus (MERS-CoV) viral shedding in the respiratory tract: an observational analysis with infection control implications. International Journal of Infectious Diseases 29: 307-308, 2014

African green monkey model of Middle East respiratory syndrome coronavirus (Mers-CoV) infection. International Journal of Infectious Diseases 79: 99-100, 2019

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Infection, Immunological Response, and Vaccine Development. Journal of Immunology Research 2019: 6491738, 2019

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics. European Review for Medical and Pharmacological Sciences 22(15): 4956-4961, 2018

MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS - MERS, MERS CoV. Disease-A-Month 63(9): 262-272, 2018