+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Compartmentalization of the chick cerebellar cortex based on the link between the striped expression pattern of aldolase C and the topographic olivocerebellar projection

Compartmentalization of the chick cerebellar cortex based on the link between the striped expression pattern of aldolase C and the topographic olivocerebellar projection

Journal of Comparative Neurology 523(13): 1886-1912

The avian cerebellum is organized into multiple longitudinal stripes defined by expression profiles of aldolase C (zebrin II) in Purkinje cells. The relationship between the aldolase C striped pattern and the olivocerebellar projection pattern is crucial in understanding cerebellar functional compartmentalization. We identified all aldolase C stripes across all lobules with the serial section alignment analysis method and then looked at this relationship by anterograde and retrograde labeling of olivocerebellar axons in the chick cerebellum. Aldolase C stripes were generally consistent and continuous from lobule I through VII and to the medial part of lobules VIII-IXb. The dorsal and ventral lamellas (DL, VL) of the inferior olive projected to the stripes in these areas with a simple mediolateral topographic relation. A few aldolase C stripes appeared at the lateral edge of lobules VI-VIII. Several more stripes were added in the lateral parts of lobules IXa-IXb and IXc-X. The medial column (MC) of the inferior olive projected to the stripes in lobules VIII-X, including the added lateral stripes, with a complex topographic relation. Sharp boundaries between aldolase C-positive and -negative stripes often accompanied a gap in the Purkinje cell layer and bordered topographically distinct groups of axons. Although the compartmental organization of the chick cerebellum is comparable to that of the mammalian cerebellum, several significant differences in the organization suggest partly separate evolutionary lineages of the mammalian and avian cerebella. We propose that rostral lobules may be evolved by rostral extension of medial stripes from caudal lobules in the avian cerebellum.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 057474175

Download citation: RISBibTeXText

PMID: 25732420

DOI: 10.1002/cne.23769

Related references

Molecular, topographic, and functional organization of the cerebellar cortex: a study with combined aldolase C and olivocerebellar labeling. Journal of Neuroscience 24(40): 8771-8785, 2004

The entire trajectories of single olivocerebellar axons in the cerebellar cortex and their contribution to Cerebellar compartmentalization. Journal of Neuroscience 21(19): 7715-7723, 2001

Identification of aldolase C compartments in the mouse cerebellar cortex by olivocerebellar labeling. Journal of Comparative Neurology 500(6): 1076-1092, 2007

Compartmentalization of the deep cerebellar nuclei based on afferent projections and aldolase C expression. Cerebellum 10(3): 449-463, 2011

Basic spatial arrangement of the olivocerebellar projection in the rat cerebellar cortex. Neuroscience Research Suppl. (24): S22, 2000

Projection of climbing fibers originating from single olivocerebellar neurons in the rat cerebellar cortex. Society for Neuroscience Abstracts 23(1-2): 1830, 1997

Topographic and zonal pattern of olivocerebellar projection to the paramedian lobule in the rabbit: an experimental study with an HRP retrograde tracing method. Neuroscience Research 7(3): 173-198, 1989

The organization of the corticonuclear and olivocerebellar climbing fiber projections to the rat cerebellar vermis: the congruence of projection zones and the zebrin pattern. Journal of Neurocytology 33(1): 5, 2004

Molecular, topographic, and functional organization of the cerebellar nuclei: analysis by three-dimensional mapping of the olivonuclear projection and aldolase C labeling. Journal of Neuroscience 27(36): 9696-9710, 2007

Parasagittal organization of the rat cerebellar cortex a direct correlation between antigenic bands revealed by monoclonal antibody q 113 and the topography of the olivocerebellar projection. Society for Neuroscience Abstracts 12(1): 464, 1986

Clustered fine compartmentalization of the mouse embryonic cerebellar cortex and its rearrangement into the postnatal striped configuration. Journal of Neuroscience 32(45): 15688-15703, 2012

The olivocerebellar projection in normal (+/+), heterozygous weaver (wv/+), and homozygous weaver (wv/wv) mutant mice: comparison of terminal pattern and topographic organization. Experimental Brain Research 95(2): 187-201, 1993

Evidence of early topographic organization in the embryonic olivocerebellar projection: a model system for the study of pattern formation processes in the central nervous system. Developmental Dynamics 197(2): 125-145, 1993

Parasagittal organization of the rat cerebellar cortex: direct correlation between antigenic Purkinje cell bands revealed by mabQ113 and the organization of the olivocerebellar projection. Journal of Comparative Neurology 265(2): 294-310, 1987

Relationship of complex spike synchrony bands and climbing fiber projection determined by reference to aldolase C compartments in crus IIa of the rat cerebellar cortex. Journal of Comparative Neurology 501(1): 13-29, 2007