+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Considerations for comprehensive assessment of genetic predisposition in familial breast cancer



Considerations for comprehensive assessment of genetic predisposition in familial breast cancer



Breast Journal 21(1): 67-75



About 10-15% of breast cancer cases are family related, classified as familial breast cancer. The disease was first reported in 1866 and determined to be an autosomal dominant genetic disease in 1971. Germline mutations in BRCA1 were discovered and deemed as the first genetic predisposition for the disease in 1994. By now, genetic predispositions for about 40% of familial breast cancer families have been identified. New molecular genetic approaches currently under development should accelerate the process to identify the full spectrum of genetic predispositions for the disease, thereby enabling a better understanding of the genetic basis of the disease and therein providing benefit to high-risk patients.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057494670

Download citation: RISBibTeXText

PMID: 25472498

DOI: 10.1111/tbj.12358


Related references

Assessment of false-negative cases of breast MR imaging in women with a familial or genetic predisposition. Breast Cancer Research and Treatment 119(2): 399-407, 2010

Genetic predisposition to cancer: familial forms of medullary thyroid cancer and breast cancer. Bulletin de l'Academie Nationale de Medecine 178(1): 123-9; Discussion 129-32, 1994

Re. Multimodality breast cancer screening in women with a familial or genetic predisposition. Current Oncology 17(6): 4-5, 2010

Multimodality breast cancer screening in women with a familial or genetic predisposition. Current Oncology 17(3): 28-36, 2010

Women's acceptance of MRI in breast cancer surveillance because of a familial or genetic predisposition. Breast 15(5): 673-676, 2006

Considerations in genetic counseling for inherited breast cancer predisposition. Seminars in Radiation Oncology 12(4): 362-370, 2002

Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. New England Journal of Medicine 351(5): 427-437, 2004

MRI screening for breast cancer in women with familial or genetic predisposition: design of the Dutch National Study (MRISC). Familial Cancer 1(3-4): 163-168, 2001

Exposure to low-dose radiation and the risk of breast cancer among women with a familial or genetic predisposition: a meta-analysis. European Radiology 20(11): 2547-2556, 2010

Differences between first and subsequent rounds of the MRISC breast cancer screening program for women with a familial or genetic predisposition. Cancer 106(11): 2318-2326, 2006

Assessment of the time-tradeoff values for prophylactic mastectomy of women with a suspected genetic predisposition to breast cancer. Medical Decision Making 18(3): 268-277, 1998

The frequency of germ-line mutations in the breast cancer predisposition genes BRCA1 and BRCA2 in familial prostate cancer. The Cancer Research Campaign/British Prostate Group United Kingdom Familial Prostate Cancer Study Collaborators. Cancer Research 60(16): 4513-4518, 2000

Polymorphisms of the DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln and Arg194Trp): relationship to breast cancer risk and familial predisposition to breast cancer. Breast Cancer Research and Treatment 95(1): 73-80, 2006

Genetic predisposition for breast carcinoma: overview of molecular genetic principles from long familial epidemiologic observation. Geburtshilfe und Frauenheilkunde 55(7): M73-M76, 1995

A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes. American Journal of Human Genetics 81(5): 873-883, 2007