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Construction of Chiral Tri- and Tetra-Arylmethanes Bearing Quaternary Carbon Centers: Copper-Catalyzed Enantioselective Propargylation of Indoles with Propargylic Esters

Tsuchida, K.; Senda, Y.; Nakajima, K.; Nishibayashi, Y.

Angewandte Chemie 55(33): 9728-9732

2016

ISSN/ISBN: 1521-3773
PMID: 27346363
DOI: 10.1002/anie.201604182
Accession: 057496462
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Copper-catalyzed enantioselective propargylation of indoles with propargylic esters and sequential Huisgen cycloaddition with azides lead to the construction of chiral triarylmethanes, bearing a quaternary carbon center, with high to excellent enantioselectivities. The result described herein can be used in the enantioselective preparation of a tetraarylmethane.

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