+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy



Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy



International Journal of Nanomedicine 10: 4425-4436



The osseointegration capacity of bone-anchoring implants can be improved by the use of drugs that are administrated by an inbuilt drug delivery system. However, to attain superior control of drug delivery and to have the ability to administer drugs of varying size, including proteins, further material development of drug carriers is needed. Mesoporous materials have shown great potential in drug delivery applications to provide and maintain a drug concentration within the therapeutic window for the desired period of time. Moreover, drug delivery from coatings consisting of mesoporous titania has shown to be promising to improve healing of bone-anchoring implants. Here we report on how the delivery of an osteoporosis drug, alendronate, can be controlled by altering pore size and surface energy of mesoporous titania thin films. The pore size was varied from 3.4 nm to 7.2 nm by the use of different structure-directing templates and addition of a swelling agent. The surface energy was also altered by grafting dimethylsilane to the pore walls. The drug uptake and release profiles were monitored in situ using quartz crystal microbalance with dissipation (QCM-D) and it was shown that both pore size and surface energy had a profound effect on both the adsorption and release kinetics of alendronate. The QCM-D data provided evidence that the drug delivery from mesoporous titania films is controlled by a binding-diffusion mechanism. The yielded knowledge of release kinetics is crucial in order to improve the in vivo tissue response associated to therapeutic treatments.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057505498

Download citation: RISBibTeXText

PMID: 26185444

DOI: 10.2147/IJN.S83005


Related references

Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release. International Journal of Nanomedicine 11: 977-990, 2016

Controlling the Pore Size of Mesoporous Carbon Thin Films through Thermal and Solvent Annealing. Small 13(15), 2017

Concentration and temperature effect on controlling pore size and surface area of mesoporous titania by using template of F-68 and F-127 co-polymer in the sol-gel process. Journal of Nanoscience and Nanotechnology 12(7): 5638-5643, 2012

Controlling pore size and uniformity of mesoporous titania by early stage low temperature stabilization. Journal of Colloid and Interface Science 391: 36-44, 2012

Pore orientation effects on the kinetics of mesostructure loss in surfactant templated titania thin films. Physical Chemistry Chemical Physics 18(4): 2896-2905, 2016

Unusual antibacterial property of mesoporous titania films: drastic improvement by controlling surface area and crystallinity. Chemistry, An Asian Journal 5(9): 1978-1983, 2010

Mesoporous titania thin films as efficient enzyme carriers for paraoxon determination/detoxification: effects of enzyme binding and pore hierarchy on the biocatalyst activity and reusability. Analyst 139(12): 3127-3136, 2015

Controlled formation of highly organized mesoporous titania thin films: from mesostructured hybrids to mesoporous nanoanatase TiO2. Journal of the American Chemical Society 125(32): 9770-9786, 2003

Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery. Chemical Communications 47(18): 5232-5234, 2011

Mesoporous TiO₂ thin films exhibiting enhanced thermal stability and controllable pore size: preparation and photocatalyzed destruction of cationic dyes. Acs Applied Materials and Interfaces 6(3): 1623-1631, 2014

Nanoparticle routes to mesoporous titania thin films. Chemical Communications 2002(18): 1738-1739, 2002

Atomic layer deposition-based tuning of the pore size in mesoporous thin films studied by in situ grazing incidence small angle X-ray scattering. Nanoscale 6(24): 14991-8, 2014

Preparation of large-pore mesoporous nanocrystalline TiO2 thin films with tailored pore diameters. Journal of Physical Chemistry. B 109(40): 18719-18722, 2006

Targeted Drug Delivery: Carbon-Quantum-Dots-Loaded Mesoporous Silica Nanocarriers with pH-Switchable Zwitterionic Surface and Enzyme-Responsive Pore-Cap for Targeted Imaging and Drug Delivery to Tumor (Adv. Healthcare Mater. 12/2016). Advanced Healthcare Materials 5(12): 1380, 2016

Tuning the wall thickness and pore orientation in mesoporous titania films prepared with low-temperature aging. Journal of Sol-Gel Science and Technology 60(1): 81-90, 2011