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Correlation of Bone Mineral Density Scores and Proton Pump Inhibitors Use in the Elderly

Correlation of Bone Mineral Density Scores and Proton Pump Inhibitors Use in the Elderly

Current Rheumatology Reviews 12(2): 162-166

We aimed to identify any correlation between long-term proton pump inhibitor use and low bone mineral density in the elderly. This is a retrospective cohort study looking at PPI usage and bone mineral density scores of patients age 65 and above within a period of two years. Lumbar spine, right hip, and left hip bone mineral density t-scores were reviewed in PPI users and non-users. A total of 1,016 patients who had bone mineral density scans within that period were identified. Non-adjusted data showed no statistically significant association between PPI users and non-users in lumbar spine (p = 0.903), right hip (p = 0.775) and left hip (p = 0.407) bone mineral density scores. After adjusting for age and gender, PPI use was still not associated with low bone mineral density at the lumbar spine (p = 0.957), right hip (p = 0.440), or left hip (p = 0.691). The logistic regression did not show a statistically significant difference in low bone mineral density scores in lumbar spine (p = 0.162), right hip (p = 0.796), and left hip (p = 0.196) when length of use was considered. Among adults 65 years and older proton pump inhibitors users; there appears to be no correlation between PPI use and low bone mineral density and/or the length of PPI use.

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Accession: 057520806

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PMID: 26496778

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