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Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus

Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus

Molecules 20(5): 7915-7924

A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7'-oxocubebin dimethylether (1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-bis(methoxymethyl)butan-1-on). The non-transformed root cultures of P. amarus showed to be a selective source of this compound. The lignan revealed strong cytotoxic activity against HeLa cell line with an IC50 value of 3.8 µg/mL.

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Accession: 057552566

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PMID: 25942372

DOI: 10.3390/molecules20057915

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