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Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus



Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarus



Molecules 20(5): 7915-7924



A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7'-oxocubebin dimethylether (1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-bis(methoxymethyl)butan-1-on). The non-transformed root cultures of P. amarus showed to be a selective source of this compound. The lignan revealed strong cytotoxic activity against HeLa cell line with an IC50 value of 3.8 µg/mL.

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Accession: 057552566

Download citation: RISBibTeXText

PMID: 25942372

DOI: 10.3390/molecules20057915


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