+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Detection of PLA2R1 in renal biopsy specimens of patients with idiopathic membranous nephropathy



Detection of PLA2R1 in renal biopsy specimens of patients with idiopathic membranous nephropathy



Nan Fang Yi Ke Da Xue Xue Bao 35(4): 526-529



To investigate the prevalence of PLA2R1 in renal biopsy specimens of patients with idiopathic membranous nephropathy (IMN) and explore the relationship between PLA2R1 and IMN. A total of 108 adult patients with biopsy-proved glomerular diseases were enrolled in this study, including 41 with IMN, 2 with hepatitis B-associated membranous nephropathy, 8 with V lupus nephritis, 27 with IgA nephropathy, 19 with minimal change nephropathy, 5 with mild mesangial proliferative glomerulonephritis, and 6 with focal segmental glomeruloselerosis (FSGS). Indirect immunofluorescence assay was used to detect PLA2R1 in the biopsy specimens and the clinical variables of the IMN patients were analyzed. In 35 of the 41 (85.37%) patients with IMN, PLA2R1 was detected with a fine granular pattern in the subepithelial deposits along the glomerular capillary loops. PLA2R1 antigen was not detected in patients with other glomerulopathies. No significant differences were found in age, serum creatinine, serum albumin, or 24-h urinary protein level between PLA2R1-positive and negative patients with IMN (P>0.05). According to our results, 85.37% of adult patients with biopsy-proven IMN are positive for PLA2R1 antigen, which, however, does not contribute to variations of the patients' clinical manifestations.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 057586682

Download citation: RISBibTeXText

PMID: 25907937


Related references

Cross-reactivity of anti-PLA2R1 autoantibodies to rabbit and mouse PLA2R1 antigens and development of two novel ELISAs with different diagnostic performances in idiopathic membranous nephropathy. Biochimie 118: 104-115, 2015

Evaluation of the staining findings of immunofluorescence in unfixed or fixed renal biopsy specimens from patients with IgA nephropathy and membranous nephropathy. Acta Pathologica Japonica 35(2): 315-321, 1985

Evaluation of anti-PLA2R1 as measured by a novel ELISA in patients with idiopathic membranous nephropathy: a cohort study. American Journal of Clinical Pathology 142(1): 29-34, 2014

Analysis of PLA2R1 and HLA-DQA1 sequence variants in Japanese patients with idiopathic and secondary membranous nephropathy. Clinical and Experimental Nephrology 22(2): 275-282, 2018

Evaluation of the staining findings of immunofluorescence in unfixed or fixed renal biopsy specimens from patients with immunoglobulin a nephropathy and membranous nephropathy. Acta Pathologica Japonica 35(2): 315-322, 1985

The Usefulness of Phospholipase A2 Receptor and IgG4 Detection in Differentiation Primary Membranous Nephropathy From Secondary Membranous Nephropathy in Renal Biopsy. Applied Immunohistochemistry and Molecular Morphology 26(8): 591-598, 2018

HLA-DQA1 and PLA2R1 polymorphisms and risk of idiopathic membranous nephropathy. Clinical Journal of the American Society of Nephrology 9(2): 335-343, 2014

Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy. Journal of the American Society of Nephrology 24(4): 677-683, 2013

Expression of type III collagen mRNA in renal biopsy specimens of patients with idiopathic membranous glomerulonephritis. Clinical Molecular Pathology 49(1): M40-M42, 1996

Rituximab for idiopathic membranous nephropathy Renal biopsy findings predict response to treatment. Journal of the American Society of Nephrology 14(Abstracts Issue): 528A, 2003

Long-term outcome of patients with lupus membranous nephropathy Comparison with idiopathic membranous nephropathy. Journal of the American Society of Nephrology 10(PROGRAM AND ABSTR ISSUE): 177A, 1999

Influence of clinical and histological features on actuarial renal survival in adult patients with idiopathic IgA nephropathy, membranous nephropathy, and membranoproliferative glomerulonephritis: survey of the recent literature. American Journal of Kidney Diseases 20(4): 315-323, 1992

Increasing frequency of idiopathic membranous nephropathy in primary glomerular disease: a 10-year renal biopsy study from a single Chinese nephrology centre. Nephrology 20(8): 560-566, 2015

Prediction of membranous nephropathy recurrence after transplantation by monitoring of anti-PLA2R1 (M-type phospholipase A2 receptor) autoantibodies: a case series of 15 patients. Nephrology Dialysis Transplantation 29(12): 2334-2342, 2014

Sp131Predictors Of Renal Survival In Patients With Idiopathic Membranous Nephropathy. Nephrology Dialysis Transplantation 32(Suppl_3): iii148-iii149, 2017