+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Diabetic Cardiovascular Disease Induced by Oxidative Stress

Diabetic Cardiovascular Disease Induced by Oxidative Stress

International Journal of Molecular Sciences 16(10): 25234-25263

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure (HF). HF represents one of the most common causes of death in patients with DM and results from DM-induced CAD and diabetic cardiomyopathy. Oxidative stress is closely associated with the pathogenesis of DM and results from overproduction of reactive oxygen species (ROS). ROS overproduction is associated with hyperglycemia and metabolic disorders, such as impaired antioxidant function in conjunction with impaired antioxidant activity. Long-term exposure to oxidative stress in DM induces chronic inflammation and fibrosis in a range of tissues, leading to formation and progression of disease states in these tissues. Indeed, markers for oxidative stress are overexpressed in patients with DM, suggesting that increased ROS may be primarily responsible for the development of diabetic complications. Therefore, an understanding of the pathophysiological mechanisms mediated by oxidative stress is crucial to the prevention and treatment of diabetes-induced CVD. The current review focuses on the relationship between diabetes-induced CVD and oxidative stress, while highlighting the latest insights into this relationship from findings on diabetic heart and vascular disease.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 057608235

Download citation: RISBibTeXText

PMID: 26512646

DOI: 10.3390/ijms161025234

Related references

Red wine protects diabetic patients from meal-induced oxidative stress and thrombosis activation: a pleasant approach to the prevention of cardiovascular disease in diabetes. European Journal of Clinical Investigation 31(4): 322-328, 2001

Mechanisms for oxidative stress in diabetic cardiovascular disease. Antioxidants and Redox Signaling 9(7): 955-969, 2007

Oxidative Stress and Antioxidant Supplementation in the Management of Diabetic Cardiovascular Disease. Journal of Investigative Medicine 52(1): 24-32, 2004

Hyperlipidaemia and cardiovascular disease: inflammation and oxidative stress in diabetic patients. Current Opinion in Lipidology 20(3): 258-259, 2009

Oxidative stress and antioxidant supplementation in the management of diabetic cardiovascular disease. Journal of Investigative Medicine 52(1): 24-32, 2004

Targeting mitochondrial oxidative stress through lipoic acid synthase: a novel strategy to manage diabetic cardiovascular disease. Cardiovascular & Hematological Agents in Medicinal Chemistry 10(3): 223-233, 2012

Is there a relationship between cystatin C and inflammatory status, oxidative stress and other cardiovascular risk factors in non-diabetic patients with chronic kidney disease?. Nefrologia 29(3): 228-235, 2009

Unraveling mechanisms of toxicant-induced oxidative stress in cardiovascular disease. Current Opinion in Toxicology 7: 1-8, 2018

Oxidative stress as a mechanism of added sugar-induced cardiovascular disease. International Journal of Angiology 23(4): 217-226, 2014

Oxidative stress and diabetic cardiovascular complications. Free Radical Biology and Medicine 40(2): 183-192, 2006

Oxidative stress-induced telomeric erosion as a mechanism underlying airborne particulate matter-related cardiovascular disease. Particle and Fibre Toxicology 9: 21, 2013

Air particulate matter induced oxidative stress and inflammation in cardiovascular disease and atherosclerosis: The role of Nrf2 and AhR-mediated pathways. Toxicology Letters 270: 88-95, 2017

Taurine ameliorates oxidative stress induced inflammation and ER stress mediated testicular damage in STZ-induced diabetic Wistar rats. Food and Chemical Toxicology 124: 64-80, 2018

Mitochondrial dysfunction, oxidative stress and diabetic cardiovascular disorders. Cardiovascular and Hematological Disorders Drug Targets 12(2): 106-112, 2013

Aldose reductase, oxidative stress and diabetic cardiovascular complications. Cardiovascular & Hematological Agents in Medicinal Chemistry 10(3): 234-240, 2012