Section 58
Chapter 57,627

Diffusion weighted imaging and apparent diffusion coefficient in 3 tesla magnetic resonance imaging of breast lesions

Caivano, R.; Villonio, A.; D' Antuono, F.; Gioioso, M.; Rabasco, P.; Iannelli, G.; Zandolino, A.; Lotumolo, A.; Dinardo, G.; Macarini, L.; Guglielmi, G.; Cammarota, A.

Cancer Investigation 33(5): 159-164


ISSN/ISBN: 1532-4192
PMID: 25831024
DOI: 10.3109/07357907.2015.1019674
Accession: 057626196

To evaluate the utility of diffusion-weighted-imaging (DWI) and apparent-diffusion-coefficient (ADC) in a 3T magnetic-resonance-imaging (MRI) study of breast cancer. In particular, the study aims to classify ADC-values according to histology either for benign or malignant lesions. 110 Breast MRI with MRI-DWI sequences and quantitative evaluation of the ADC were retrospectively reviewed. Results obtained with MRI-DWI and with biopsy were analyzed and ADC values were compared to histological results. MRI showed a 95.5% sensitivity and a 83.7% specificity. The mean ADC values of benign and malignant lesions were 2.06 ± 0.19 and 1.03 ± 0.07 mm(2)/s, respectively (p < .05). DWI and ADC-values could help distinguishing malignant and benign breast masses.

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