Direct Asymmetric Reductive Amination for the Synthesis of Chiral β-Arylamines

Huang, H.; Liu, X.; Zhou, L.; Chang, M.; Zhang, X.

Angewandte Chemie 55(17): 5309-5312


ISSN/ISBN: 1521-3773
PMID: 26992130
DOI: 10.1002/anie.201601025
Accession: 057628855

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The highly efficient and direct asymmetric reductive amination of arylacetones catalyzed by an iridium complex for the preparation of enantiomerically pure β-arylamines is described. The monodentate phosphoramidite ligand exhibits superb reactivity (TONs of up to 20 000) and enantioselectivity (up to 99 % ee). Additives played important roles in this reductive coupling reaction.