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Dual-energy computed tomography: a promising novel preoperative localization study for treatment of primary hyperparathyroidism



Dual-energy computed tomography: a promising novel preoperative localization study for treatment of primary hyperparathyroidism



American Journal of Surgery 211(5): 839-845



The objective of this study was to evaluate dual-energy computed tomography (DE-CT) for preoperative parathyroid tumor (PT) localization in individuals undergoing parathyroidectomy for treatment of primary hyperparathyroidism (PHP). DE-CT was evaluated by retrospective review of the clinical and biochemical characteristics, imaging, operative findings, and outcomes for PHP cases undergoing an initial operation at a single center. The accuracy of each preoperative imaging test, based on operative findings and pathological confirmation of removal of a PT from the localized site was: 58% for ultrasound, 75% Tc-99m sestamibi noncontrast single photon emission noncontrast CT, and 75% for DE-CT. DE-CT was able to correctly localize a PT in a 3rd of cases that were nonlocalized. All study patients had normalization of serum calcium and parathyroid hormone levels postoperatively. DE-CT shows promise for the preoperative PT localization, especially in nonlocalized PHP cases, and warrants further investigation.

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Accession: 057667518

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PMID: 26997304

DOI: 10.1016/j.amjsurg.2016.01.003


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