EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Early Diet and Later Cancer Risk: Prospective Associations of Dietary Patterns During Critical Periods of Childhood with the GH-IGF Axis, Insulin Resistance and Body Fatness in Younger Adulthood






Nutrition and Cancer 67(6): 877-892

Early Diet and Later Cancer Risk: Prospective Associations of Dietary Patterns During Critical Periods of Childhood with the GH-IGF Axis, Insulin Resistance and Body Fatness in Younger Adulthood

Early life, adiposity rebound, and puberty represent critical growth periods when food choices could have long-term relevance for cancer risk. We aimed to relate dietary patterns during these periods to the growth hormone-insulin-like-growth-factor (GH-IGF) axis, insulin resistance, and body fatness in adulthood. Data from the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) Study participants with outcome data at 18-37 years, and ≥2 dietary records during early life (1-2 yr; n = 128), adiposity rebound (4-6 years, n = 179), or puberty (girls 9-14, boys 10-15 yr; n = 213) were used. Dietary patterns at these ages were derived by 1) reduced rank regression (RRR) to explain variation in adult IGF-I, IGF-binding protein-3 (IGFBP-3), homoeostasis model assessment for insulin resistance (HOMA-IR) and fat-mass index; 2) principal component analysis (PCA). Regarding RRR, the patterns "cake/canned fruit/cheese & eggs" (early life), "sweets & dairy" (adiposity rebound) and "high-fat foods" (pubertal boys) were independently associated with higher adult HOMA-IR. Furthermore, the patterns "favorable carbohydrate sources" (early life), "snack & convenience foods" (adiposity rebound), and "traditional & convenience carbohydrates" (pubertal boys) were related to adult IGFBP-3 (P trend < 0.01). PCA identified "healthy" patterns for all periods, but none was associated with the outcomes (P trend > 0.1). In conclusion, dietary patterns during sensitive growth periods may be of long-term relevance for adult insulin resistance and IGFBP-3.


Accession: 057678216

PMID: 26226486

DOI: 10.1080/01635581.2015.1056313



Related references

Sinaiko, A.R.; Jacobs, D.R.; Steinberger, J.; Moran, A.; Luepker, R.; Rocchini, A.P.; Prineas, R.J., 2001: Insulin resistance syndrome in childhood: associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors. Objective: Our objective was to describe in children the relation of fatness and insulin resistance to the risk factors associated with the insulin resistance syndrome and to compare fasting insulin with the euglycemic insulin clamp as a measure o...

Günther, A.L.B.; Walz, H.; Kroke, A.; Wudy, S.A.; Riedel, C.; von Kries, Rüdiger.; Joslowski, G.; Remer, T.; Cheng, G.; Buyken, A.E., 2014: Breastfeeding and its prospective association with components of the GH-IGF-Axis, insulin resistance and body adiposity measures in young adulthood--insights from linear and quantile regression analysis. Breastfeeding may lower chronic disease risk by long-term effects on hormonal status and adiposity, but the relations remain uncertain. To prospectively investigate the association of breastfeeding with the growth hormone- (GH) insulin-like growth...

Yajnik, C.S.; Katre, P.A.; Joshi, S.M.; Kumaran, K.; Bhat, D.S.; Lubree, H.G.; Memane, N.; Kinare, A.S.; Pandit, A.N.; Bhave, S.A.; Bavdekar, A.; Fall, C.H.D., 2016: Higher glucose, insulin and insulin resistance (HOMA-IR) in childhood predict adverse cardiovascular risk in early adulthood: the Pune Children's Study. The Pune Children's Study aimed to test whether glucose and insulin measurements in childhood predict cardiovascular risk factors in young adulthood. We followed up 357 participants (75% follow-up) at 21 years of age who had undergone detaile...

Martin, R.M.; Holly, J.M.P.; Davey Smith, G.; Gunnell, D., 2006: Associations of adiposity from childhood into adulthood with insulin resistance and the insulin-like growth factor system: 65-year follow-up of the Boyd Orr Cohort. Context: One metabolic pathway through which adiposity influences disease risk may be via alterations in insulin and IGF metabolism. Objective: Our objective was to investigate associations of adiposity at different stages of life with insulin and...

Tonorezos, E.S.; Vega, G.L.; Sklar, C.A.; Chou, J.F.; Moskowitz, C.S.; Mo, Q.; Church, T.S.; Ross, R.; Janiszewski, P.M.; Oeffinger, K.C., 2012: Adipokines, body fatness, and insulin resistance among survivors of childhood leukemia. Following our previous reports of an increased prevalence of insulin resistance and adiposity among acute lymphoblastic leukemia (ALL) survivors, particularly women treated with cranial radiotherapy (CRT), we aimed to (1) assess the relationships...

Song, Y.; Manson, J.E.; Buring, J.E.; Sesso, H.D.; Liu, S., 2005: Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis. OBJECTIVE: Flavonoids, as antioxidants, may prevent the progressive impairment of pancreatic {szligbeta}-cell function due to oxidative stress and may thus reduce the occurrence of type 2 diabetes. The aim of the present study was to examine the a...

Mishra, G.D.; dos Santos Silva, I.; McNaughton, S.A.; Stephen, A.; Kuh, D., 2011: Energy intake and dietary patterns in childhood and throughout adulthood and mammographic density: results from a British prospective cohort. To examine the role of energy intake and dietary patterns in childhood and throughout adulthood on subsequent mammographic density. Prospective data were available from a cohort of 1161 British women followed up since their birth in 1946. Dietary...

Srinivasan, S.R.; Myers, L.; Berenson, G.S., 2001: Childhood adiposity is a better predictor than insulin for the risk of developing insulin resistance syndrome in adulthood The Bogalusa Heart Study. Circulation 104(17 Supplement): II 804, October 23

Voerman, E.; Jaddoe, V.W.V.; Franco, O.H.; Steegers, E.A.P.; Gaillard, R., 2016: Critical periods and growth patterns from fetal life onwards associated with childhood insulin levels. We aimed to identify critical periods and specific longitudinal growth patterns from fetal life onwards associated with childhood insulin and C-peptide levels. In a prospective population-based cohort study of 4328 children, we repeatedly measured...

Vitonis, A.F.; Baer, H.J.; Hankinson, S.E.; Laufer, M.R.; Missmer, S.A., 2010: A prospective study of body size during childhood and early adulthood and the incidence of endometriosis. An inverse association between adult body mass index (BMI) and risk of endometriosis has frequently been reported. However, the association between body size during childhood and early adulthood and endometriosis is not as well documented. Using d...