+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of dietary fish oil on the expression of genes involved in lipid metabolism in liver and skeletal muscle of lactating sows



Effect of dietary fish oil on the expression of genes involved in lipid metabolism in liver and skeletal muscle of lactating sows



Journal of Animal Physiology and Animal Nutrition 100(2): 337-347



This study investigated the hypothesis that dietary supplementation of fish oil as a source of n-3 polyunsaturated fatty acids (PUFA) influences the expression of target genes of sterol regulatory element-binding proteins (SREBP)-1 and (SREBP)-2 involved in triacylglycerol (TAG) synthesis and fatty acid and cholesterol metabolism in the liver, and moreover activates the expression of target genes of peroxisome proliferation-activated receptor (PPAR)-α involved in TAG and fatty acid catabolism in liver and skeletal muscle. Twenty lactating sows were fed a control diet or a fish oil diet with either 50 g of a mixture of palm oil and soya bean oil (4:1, w/w) or fish oil per kg. The diet of the fish oil group contained 19.1 g of n-3 PUFA (mainly 20:5 n-3 and 22:6 n-3) per 100 g of total fatty acids, while the diet of the control group contained 2.4 g of n-3 PUFA (mainly 18:3 n-3) per 100 g of total fatty acids. The fish oil group had reduced relative mRNA concentrations of various target genes of SREBP-1 involved in fatty acid and TAG synthesis in comparison with the control group (p < 0.05). Relative mRNA concentrations of target genes of PPARα involved in fatty acid catabolism in both liver and muscle, and mRNA concentrations of target genes of SREBP-2 involved in cholesterol synthesis and uptake were not influenced by fish oil supplementation. Concentrations of cholesterol and TAG in plasma, fat content of milk and weight gains of litters during the suckling period were not different between the two groups of sows. In conclusion, this study suggests that fish oil has only minor effects on hepatic lipid metabolism, which are non-critical with respect to milk production in sows.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057702700

Download citation: RISBibTeXText

PMID: 25865806

DOI: 10.1111/jpn.12324


Related references

Effects of dietary fish protein on serum and liver lipid concentrations in rats and the expression of hepatic genes involved in lipid metabolism. Journal of Agricultural and Food Chemistry 57(19): 9256-9262, 2010

Expression of genes involved in lipid metabolism correlate with peroxisome proliferator-activated receptor gamma expression in human skeletal muscle. Journal of Clinical Endocrinology and Metabolism 85(11): 4293-4297, 2000

Effects of pasture versus confinement and marine oil supplementation on the expression of genes involved in lipid metabolism in mammary, liver, and adipose tissues of lactating dairy cows. Journal of Dairy Science 97(7): 4174-4183, 2015

Dietary protein intake affects expression of genes for lipid metabolism in porcine skeletal muscle in a genotype-dependent manner. British Journal of Nutrition 113(7): 1069-1077, 2015

Analysis of allele-specific expression of seven candidate genes involved in lipid metabolism in pig skeletal muscle and fat tissues reveals allelic imbalance of ACACA, LEP, SCD, and TNF. Journal of Applied Genetics 2019, 2019

The function of porcine PPARγ and dietary fish oil effect on the expression of lipid and glucose metabolism related genes. Journal of Nutritional Biochemistry 22(2): 179-186, 2011

Effect of dietary fish oil and corn oil on lipid metabolism and apolipoprotein gene expression by rat liver. European Journal of Biochemistry 196(2): 499-508, 1991

mRNA expression of genes involved in fatty acid utilization in skeletal muscle and white adipose tissues of sows during lactation. Comparative Biochemistry and Physiology. Part A, Molecular and Integrative Physiology 158(4): 450-454, 2011

Effect of dietary α-lipoic acid on the mRNA expression of genes involved in drug metabolism and antioxidation system in rat liver. British Journal of Nutrition 112(3): 295-308, 2014

Dietary Conjugated Linoleic Acid Lowered Tumor Necrosis Factor- Content and Altered Expression of Genes Related to Lipid Metabolism and Insulin Sensitivity in the Skeletal Muscle of Zucker Rats. Journal of agricultural and food chemistry4 54(20): 7935-7939, 2006

The effect of dietary fat on the energy metabolism of lactating sows and on the performance of sows and their piglets: a review. Allattenyesztes es Takarmanyozas 50(1): 69-82, 2001

Dietary conjugated linoleic acid lowered tumor necrosis factor-alpha content and altered expression of genes related to lipid metabolism and insulin sensitivity in the skeletal muscle of Zucker rats. Journal of Agricultural and Food Chemistry 54(20): 7935-7939, 2006

Effect of unsaturated fat intake from Mediterranean diet on rat liver mRNA expression profile: selective modulation of genes involved in lipid metabolism. Nutrition, Metabolism, and Cardiovascular Diseases 15(1): 13-23, 2005

Dietary supplementation with soy isoflavones or replacement with soy proteins prevents hepatic lipid droplet accumulation and alters expression of genes involved in lipid metabolism in rats. Genes and Nutrition 9(1): 373, 2013

Effect of diet on expression of genes involved in lipid metabolism, oxidative stress, and inflammation in mouse liver-insights into mechanisms of hepatic steatosis. Plos One 9(2): E88584, 2014