+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of eradication of Helicobacter pylori on expression levels of FHIT, IL-8 and P73 in gastric mucosa of first-degree relatives of gastric cancer patients



Effect of eradication of Helicobacter pylori on expression levels of FHIT, IL-8 and P73 in gastric mucosa of first-degree relatives of gastric cancer patients



Plos One 10(4): E0124576



Helicobacter pylori (H. pylori) infection plays an important role in the carcinogenesis and development of gastric cancer. Eradication of H. pylori can effectively reduce the risk of gastric cancer, but the underlying mechanisms are not fully understood. This study aimed to investigate the effect of eradication of H. pylori on the expression levels of FHIT, IL-8 and P73 in the gastric mucosa of first-degree relatives of gastric cancer patients. One hundred and thirty-two patients with functional dyspepsia having first-degree relatives with gastric cancer were prospectively recruited in this study. Nine patients presented with H. pylori infection and family histories of gastric cancer, 61 with H. pylori infection and without family histories of gastric cancer, 6 without H. pylori infection and with family histories of gastric cancer, and 56 without H. pylori infection and family histories of gastric cancer. The protein and mRNA expression levels of FHIT, IL-8 and P73 in gastric mucosa of the subjects were detected by immunohistochemical staining and polymerase chain reaction, respectively. Compared with the patients without H. pylori infection and family histories of gastric cancer, both the protein and mRNA levels of FIHT significantly decreased in patients with H. pylori infection and/or family histories of gastric cancer, and both the protein and mRNA levels of IL-8 significantly increased. After eradication of H. pylori, both the protein and mRNA levels of FHIT were significantly higher, and both the protein and mRNA levels of IL-8 were significantly lower. However, H. pylori infection and family histories of gastric cancer had no major effect on P73 expression. Down-regulation of FHIT and up-regulation of IL-8 may be involved in the pathogenesis of H. pylori infection in the first-degree relatives of gastric cancer patients.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 057703629

Download citation: RISBibTeXText

PMID: 25875960


Related references

Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection. World Journal of Gastroenterology 11(1): 17-21, 2004

Effect of Helicobacter pylori eradication on the expression level of SATB1 and c-Myc genes in gastric mucosa of patients with family history of gastric cancer. Polski Merkuriusz Lekarski 34(203): 269-276, 2013

Helicobacter pylori infection and family history of gastric cancer decrease expression of FHIT tumor suppressor gene in gastric mucosa of dyspeptic patients. Helicobacter 14(5): 126-134, 2009

The influence of Helicobacter pylori eradication on the expression and methylation status of the FHIT gene in non-cancerous gastric mucosa of dyspeptic patients. Journal of Digestive Diseases 16(7): 385-394, 2016

Increased expression of cyclooxygenase-2 in gastric carcinoma, in the gastric mucosa of healthy first-degree relatives, and in relation to Helicobacter pylori infection. Gut 47(Suppl. 1): A72, 2000

Role of metallothionein in Helicobacter pylori-positive gastric mucosa with or without early gastric cancer and the effect on its expression after eradication therapy. Journal of Gastroenterology and Hepatology 23(8 Pt 2): E334-E339, 2007

Analysis of the differences in structural chromosomal aberrations of the gastric mucosa between H-pylori positive and negative gastric cancer patients: Involvement of H-pylori in the onset of gastric cancer and examination of the mechanism in gastric carcinogenesis following H-pylori eradication. Oncology Reports 16(6): 1333-1342, 2006

Helicobacter pylori infection and gastric histology in first-degree relatives of gastric cancer patients: a meta-analysis. European Journal of Gastroenterology and Hepatology 22(9): 1128-1133, 2010

Expression of transforming growth factor beta-1 in gastric cancer and in the gastric mucosa of first-degree relatives of patients with gastric cancer. British Journal of Cancer 82(11): 1795-1800, 2000

Effects of Helicobacter pylori eradication on the background gastric mucosa in the patients after endoscopic mucosal resection of early gastric cancer. Gastroenterology 118(4 Suppl 2 Part 1): AGA A502, 2000

Higher gastric cycloxygenase-2 expression and precancerous change in Helicobacter pylori-infected relatives of gastric cancer patients. Clinical Cancer Research 9(14): 5245-5251, 2003

Relation of lactoferrin levels in gastric mucosa with Helicobacter pylori infection and with the degree of gastric inflammation. American Journal of Gastroenterology 92(6): 1005-1011, 1997

Effect of Helicobacter pylori eradication on epithelial cell turnover and p53 expression of the gastric mucosa in patients with chronic gastritis Comparison between intestinal metaplastic and non-metaplastic mucosa. Gastroenterology 120(5 Suppl. 1): A 588-A 589, 2001

Effect of Helicobacter pylori eradication on epithelial cell turnover and p53 expression of the gastric mucosa in patients with chronic gastritis-comparison between intestinal metaplastic and non-metaplastic mucosa. Gastroenterology 120(5): A588-A589, 2001

Helicobacter pylori infection in 1st degree relatives of Chinese gastric cancer patients. Scandinavian Journal of Gastroenterology 41(3): 274-279, 2006