EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Effect of supplemental lutein and zeaxanthin on serum, macular pigmentation, and visual performance in patients with early age-related macular degeneration


Effect of supplemental lutein and zeaxanthin on serum, macular pigmentation, and visual performance in patients with early age-related macular degeneration



Biomed Research International 2015: 564738



ISSN/ISBN: 2314-6133

PMID: 25815324

DOI: 10.1155/2015/564738

To compare the 2-year effect of multiple doses of lutein/zeaxanthin on serum, macular pigmentation, and visual performance on patients with early age-related macular degeneration (AMD). In this randomized, double-blinded, and placebo-controlled trial, 112 early AMD patients randomly received either 10 mg lutein, 20 mg lutein, a combination of lutein (10 mg) and zeaxanthin (10 mg), or placebo daily for 2 years. Serum concentration of lutein/zeaxanthin, macular pigment optical density (MPOD), visual functions including best-spectacle corrected visual acuity (BCVA), contrast sensitivity (CS), flash recovery time (FRT), and vision-related quality of life (VFQ25) was quantified. Serum lutein concentration and MPOD significantly increased in all the active treatment groups. Supplementation with 20 mg lutein was the most effective in increasing MPOD and CS at 3 cycles/degree for the first 48 weeks. However, they both significantly increased to the same peak value following supplementation with either 10 mg or 20 mg lutein during the intervention. No statistical changes of BCVA or FRT were observed during the trial. Long-term lutein supplementation could increase serum lutein concentration, MPOD, and visual sensitivities of early AMD patients. 10 mg lutein daily might be an advisable long-term dosage for early AMD treatment.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057710467

Download citation: RISBibTeXText

Related references

Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration. Ophthalmology 119(11): 2290-2297, 2012

Comparison of daily intake of lutein+zeaxanthin, serum concentration of lutein/zeaxanthin and lipids profile between age-related macular degeneration patients and controls. Beijing da Xue Xue Bao. Yi Xue Ban 46(2): 237-241, 2014

Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. Investigative Ophthalmology and Visual Science 56(1): 252-258, 2014

Macular pigment and serum zeaxanthin levels with Goji berry supplement in early age-related macular degeneration. International Journal of Ophthalmology 11(6): 970-975, 2018

Lycopene but not lutein nor zeaxanthin decreases in serum and lipoproteins in age-related macular degeneration patients. Clinica Chimica Acta; International Journal of Clinical Chemistry 357(1): 34-42, 2005

Does dietary lutein and zeaxanthin increase the risk of age related macular degeneration? The Melbourne Visual Impairment Project. British Journal of Ophthalmology 90(3): 389-390, 2006

Macular pigment density variation after supplementation of lutein and zeaxanthin using the Visucam ® 200 pigment module: Impact of age-related macular degeneration and lens status. Journal Francais d'Ophtalmologie 40(4): 303-313, 2017

Association between Dietary Xanthophyll (Lutein and Zeaxanthin) Intake and Early Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study. Ophthalmic Epidemiology 24(5): 311-322, 2017

Lutein, zeaxanthin, and age-related macular degeneration. Journal of Nutraceuticals, Functional and Medical Foods 3(1): 79-85, 2000

Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial. American Journal of Ophthalmology 154(4): 625-634.E1, 2012

Changes following supplementation with lutein and zeaxanthin in retinal function in eyes with early age-related macular degeneration: a randomised, double-blind, placebo-controlled trial. British Journal of Ophthalmology 99(3): 371-375, 2015

Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration. Investigative Ophthalmology and Visual Science 52(11): 8174-8178, 2011

Associations between lutein, zeaxanthin, and age-related macular degeneration: an overview. Critical Reviews in Food Science and Nutrition 49(4): 313-326, 2009

Lutein and zeaxanthin dietary intake and age related macular degeneration. British Journal of Ophthalmology 90(7): 927-928, 2006

Lutein and zeaxanthin status and risk of age-related macular degeneration. IOVS Investigative Ophthalmology and Visual Science 44(6): 2461-2465, 2003