+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of a weight loss program on body composition and the metabolic profile in obese postmenopausal women displaying various obesity phenotypes: a MONET group study



Effects of a weight loss program on body composition and the metabolic profile in obese postmenopausal women displaying various obesity phenotypes: a MONET group study



Applied Physiology Nutrition and Metabolism 40(7): 695-702



Obesity is a heterogeneous condition, since the metabolic profile may differ greatly from one individual to another. The objective of this study was to compare the effect of a 6-month diet-induced weight loss program on body composition and the metabolic profile in obese individuals displaying different obesity phenotypes. Secondary analyses were done on 129 obese (% body fat: 46% ± 4%) postmenopausal women (age: 57 ± 4 years). Outcome measures included body composition, body fat distribution, glucose homeostasis, fasting lipids, and blood pressure. Obesity phenotypes were determined based on lean body mass (LBM) index (LBMI = LBM/height(2)) and visceral fat (VF) accumulation, as follows: 1, lower VF and lower LBMI (n = 35); 2, lower VF and higher LBMI (n = 19); 3, higher VF and lower LBMI (n = 14); and 4, higher VF and higher LBMI (n = 61). All groups had significantly improved measures of body composition after the intervention (P < 0.0001). Greater decreases in LBM and LBMI were observed in the higher LBMI groups than in the lower LBMI groups (P < 0.0001). Similarly, decreases in VF were greater in the higher VF groups than in the lower VF groups (P < 0.05). Overall, fasting insulin levels and glucose disposal improved following the intervention, with higher LBMI groups showing a trend for greater improvements (P = 0.06 and 0.07, respectively). Overall, no difference was observed among the different obesity phenotypes regarding improvements in the metabolic profile in response to weight loss. Individuals displaying higher VF or higher LBMI at baseline experienced significantly greater decreases for these variables after the intervention.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057723954

Download citation: RISBibTeXText

PMID: 26140414

DOI: 10.1139/apnm-2014-0451


Related references

Effects of a 6-month caloric restriction induced-weight loss program in obese postmenopausal women with and without the metabolic syndrome: a MONET study. Menopause 24(8): 908-915, 2017

Body composition determinants of metabolic phenotypes of obesity in nonobese and obese postmenopausal women. Obesity 21(9): 1807-1814, 2013

Effects of rapid or slow weight loss on body composition and metabolic risk factors in obese postmenopausal women. A pilot study. Appetite 58(3): 831-834, 2012

Resistance training does not contribute to improving the metabolic profile after a 6-month weight loss program in overweight and obese postmenopausal women. Journal of Clinical Endocrinology and Metabolism 94(9): 3226-3233, 2009

Anthropometric, metabolic, psychosocial and dietary factors associated with dropout in overweight and obese postmenopausal women engaged in a 6-month weight loss programme: a MONET study. British Journal of Nutrition 103(8): 1230-1235, 2010

Effects of a popular exercise and weight loss program on weight loss, body composition, energy expenditure and health in obese women. Nutrition and Metabolism 6: 23, 2009

Metabolic profile and quality of life in class I sarcopenic overweight and obese postmenopausal women: a MONET study. Applied Physiology, Nutrition, and Metabolism 34(1): 18-24, 2009

Association between Abdominal Fat (DXA) and Its Subcomponents (CT Scan) before and after Weight Loss in Obese Postmenopausal Women: A MONET Study. Journal of Obesity 2011: 239516, 2011

A one-year resistance training program following weight loss has no significant impact on body composition and energy expenditure in postmenopausal women living with overweight and obesity. Physiology & Behavior 189: 99-106, 2018

Obesity in elderly women Body composition-metabolic effects of weight loss. FASEB Journal 12(5): A652, 1998

Effects of dietary and exercise intervention on weight loss and body composition in obese postmenopausal women: a systematic review and meta-analysis. Menopause 25(7): 772-782, 2018

Body composition and metabolic effects of a diet and exercise weight loss regimen on obese, HIV-infected women. Metabolism: Clinical and Experimental 55(10): 1327-1336, 2006

Comparison of simple indices for measuring insulin resistance that integrates adipokines in non-diabetic obese postmenopausal women before and after weight loss: A MONET study. Diabetes and Metabolism 44(2): 190-191, 2018

Short- and long-term effects of continuous versus intermittent restrictive diet approaches on body composition and the metabolic profile in overweight and obese postmenopausal women: a pilot study. Menopause 19(8): 870-876, 2012

Role of Calcium and Low-Fat Dairy Foods in Weight-Loss Outcomes Revisited: Results from the Randomized Trial of Effects on Bone and Body Composition in Overweight/Obese Postmenopausal Women. Nutrients 11(5):, 2019