+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of boric acid on the healing of Achilles tendons of rats

Effects of boric acid on the healing of Achilles tendons of rats

Knee Surgery Sports Traumatology Arthroscopy 24(12): 3738-3744

Tendinous lesions are among the most frequent pathologies encountered in sportsmen. The objectives of new treatments are to improve the healing process and reduce the recovery time. Boron plays an important role in the wound repair process by increasing components of extracellular matrix and angiogenesis. This animal study aimed to investigate the effect of boric acid on healing of the Achilles tendon. The right Achilles tendons of 40 rats were completely sectioned, and the rats were randomly divided into five groups. Each group consisted of eight rats. Groups 1 and 2 were oral boric acid groups with the doses of 4 and 8 mg/kg/day boric acid, respectively. Group 3 was the local boric acid group (8 mg/kg boric acid intratendinous injection). Group 4 was administered both oral and local boric acid (8 mg/kg/day orally and 8 mg/kg boric acid intratendinous injection), and group 5 was the control group with no boric acid application. At the end of the fourth week, all the rats were killed and histopathological examination of the Achilles tendon repair site was made. Histopathological examination of the tissue sections revealed more properly oriented collagen fibres, more normal cellular distribution of tenocytes and more properly organized vascular bundles in group 1 and group 2, which were the groups administered oral boric acid. Pathological sum scores of groups 1 and 2 were less than those of the other groups, and the differences between the oral boric acid groups (group 1 and group 2) and the other three groups (groups 3, 4 and 5) were statistically significant (p = 0.001). As boric acid is safe and toxicity even after very high doses is unusual, oral boric acid may be used as an agent to improve the healing process of tendon injuries. However, biomechanical tests should also be performed to show the effect of boric acid on strength and endurance of the tendon before it can be used in clinical practice.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 057725420

Download citation: RISBibTeXText

PMID: 25931129

DOI: 10.1007/s00167-015-3617-5

Related references

Effects of platelet-rich plasma (PRP) on the healing of Achilles tendons of rats. Wound Repair and Regeneration 20(5): 748-756, 2013

Histological and biomechanical analysis of the effects of streptozotocin-induced type one diabetes mellitus on healing of tenotomised Achilles tendons in rats. Foot and Ankle Surgery 20(3): 186-191, 2014

Tenocytes from ruptured and tendinopathic achilles tendons produce greater quantities of type III collagen than tenocytes from normal achilles tendons. An in vitro model of human tendon healing. American Journal of Sports Medicine 28(4): 499-505, 2000

A cryo-jaw designed for in vitro tensile testing of the healing Achilles tendons in rats. Journal of Biomechanics 37(11): 1719-1722, 2004

The structure of tendons during various age periods and under various functional conditions. I. A quantitative morphologic investigation of the Achilles tendon in white rats. II. An electron-microscopic investigation of achilles tendons from white rats. Acta Anat [basel] 6(1/2-3): 113-140, 193-225, 1948

Effects of botulinum toxin A injection on healing and tensile strength of ruptured rabbit Achilles tendons. Annals of Plastic Surgery 74(4): 496-500, 2015

The struoture of tendons at various ages and under different functional conditions. II. An electron-microscopic investigation of Achilles tendons from white Rats. Acta Anatomica Basel 6: 193-225, 1948

Impregnation of Tawa (Beilschimieda tawa Benth. and Hook. f.) with boric acid by diffusion. I. Changes in distribution of boric acid with time after treatment. II. Effects of some variables upon loading and distribution of boric acid in this timber. N.Z. J. Sci. Technol, 32B: 4, 28-38, 1951

Substantial creep in healing human Achilles tendons. A pilot study. Muscles Ligaments and Tendons Journal 5(3): 151-155, 2015

Laser photostimulation of collagen production in healing rabbit Achilles tendons. Lasers in Surgery and Medicine 22(5): 281-287, 1998

Primary gene response to mechanical loading in healing rat Achilles tendons. Journal of Applied Physiology 114(11): 1519-1526, 2013

An in-vivo experimental evaluation of He-Ne laser photostimulation in healing Achilles tendons. Lasers in Medical Science 22(1): 53-59, 2007

Effects of interleukin-1 receptor antagonist on collagen and matrix metalloproteinases in stress-shielded achilles tendons of rats. Orthopedics 35(8): E1238-E1244, 2012

Effects of Boric Acid on Fracture Healing: An Experimental Study. Biological Trace Element Research 167(2): 264-271, 2015

Influence of a single loading episode on gene expression in healing rat Achilles tendons. Journal of Applied Physiology 112(2): 279-288, 2012