+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Effects of two whole-grain barley varieties on caecal SCFA, gut microbiota and plasma inflammatory markers in rats consuming low- and high-fat diets



Effects of two whole-grain barley varieties on caecal SCFA, gut microbiota and plasma inflammatory markers in rats consuming low- and high-fat diets



British Journal of Nutrition 113(10): 1558-1570



Mixed-linkage β-glucans are fermented by the colon microbiota that give rise to SCFA. Propionic and butyric acids have been found to play an important role in colonic health, as well as they may have extraintestinal metabolic effects. The aim of the present study was to investigate how two whole-grain barley varieties differing in dietary fibre and β-glucan content affected caecal SCFA, gut microbiota and some plasma inflammatory markers in rats consuming low-fat (LF) or high-fat (HF) diets. Barley increased the caecal pool of SCFA in rats fed the LF and HF diets compared with those fed the control diet, and the effect was generally dependent on fibre content, an exception was butyric acid in the LF setting. Furthermore, whole-grain barley reduced plasma lipopolysaccharide-binding protein and monocyte chemoattractant protein-1, increased the caecal abundance of Lactobacillus and decreased the Bacteroides fragilis group, but increased the number of Bifidobacterium only when dietary fat was consumed at a low level. Fat content influenced the effects of barley: rats fed the HF diets had a higher caecal pool of acetic and propionic acids, higher concentrations of amino acids and higher amounts of lipids in the portal plasma and liver than rats fed the LF diets; however, less amounts of butyric acid were generally formed. Interestingly, there was an increase in the caecal abundance of Akkermansia and the caecal pool of succinic acid, and a decrease in the proportion of Bifidobacterium and the Clostridium leptum group. In summary, whole-grain barley decreased HF diet-induced inflammation, which was possibly related to the formation of SCFA and changes in microbiota composition. High β-glucan content in the diet was associated with reduced plasma cholesterol levels.

(PDF emailed within 0-6 h: $19.90)

Accession: 057735751

Download citation: RISBibTeXText

PMID: 25864430

DOI: 10.1017/S0007114515000793


Related references

Effects of monobutyrin and tributyrin on liver lipid profile, caecal microbiota composition and SCFA in high-fat diet-fed rats. Journal of Nutritional Science 6: E51-E51, 2017

Modulation of gut microbiota in rats fed high-fat diets by processing whole-grain barley to barley malt. Molecular Nutrition & Food Research 59(10): 2066-2076, 2016

High-grain feeding alters caecal bacterial microbiota composition and fermentation and results in caecal mucosal injury in goats. British Journal of Nutrition 112(3): 416-427, 2014

Changes in Lipids and Inflammatory Markers after Consuming Diets High in Red Meat or Dairy for Four Weeks. Nutrients 9(8): -, 2018

Effects of convenience rice congee supplemented diets on guinea pig whole animal and gut growth, caecal digesta SCFA and in vitro ileal contractility. Asia Pacific Journal of Clinical Nutrition 13(1): 92-100, 2004

Effect of β -glucanase and xylanase supplementation of barley- and rye-based diets on caecal microbiota of broiler chickens. British Poultry Science 51(4): 546-557, 2011

Evaluation of commercial microbial hydrocolloids concerning their effects on plasma lipids and caecal formation of SCFA in mice. Food Hydrocolloids 28(2): 367-372, 2012

Effects of oat bran, processed to different molecular weights of beta-glucan, on plasma lipids and caecal formation of SCFA in mice. British Journal of Nutrition 104(3): 364-373, 2010

Differential effects of dietary whey, casein and soya on colonic DNA damage and large bowel SCFA in rats fed diets low and high in resistant starch. British Journal of Nutrition 97(3): 535-543, 2007

Molecular and microbiological analysis of caecal microbiota in rats fed with diets supplemented either with prebiotics or probiotics. International Journal of Food Microbiology 98(3): 281-289, 2005

Changes in composition a metabolism of caecal microbiota in rats fed diets supplemented with copper-loaded chitosan nanoparticles. Journal of Animal Physiology and Animal Nutrition 94(5): E138-E144, 2011

Caecal content of SCFA in rats fed three different raw and processed plant foods. Malkki, Y, Cummings, J H COST Action 92 Dietary fibre and fermentation in the colon: 159-162, 1996

Mannan- and xylooligosaccharides modulate caecal microbiota and expression of inflammatory-related cytokines and reduce caecal Salmonella Enteritidis colonisation in young chickens. Fems Microbiology Ecology 93(1): -, 2016

Extrusion of barley and oat influence the fecal microbiota and SCFA profile of growing pigs. Food & Function 7(2): 1024-1032, 2016

Protein utilization and caecal fermentation in rats fed on wheat-, barley- or naked oat-diets supplemented with beta -glucanase. Journal of Animal and Feed Sciences 13(4): 665-676, 2004