+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Elevated HbA(1c) levels and the accumulation of differentiated T cells in CMV(+) individuals



Elevated HbA(1c) levels and the accumulation of differentiated T cells in CMV(+) individuals



Diabetologia 58(11): 2596-2605



Biological ageing of the immune system, or immunosenescence, predicts poor health and increased mortality. A hallmark of immunosenescence is the accumulation of differentiated cytotoxic T cells (CD27(-)CD45RA(+/-); or dCTLs), partially driven by infection with the cytomegalovirus (CMV). Immune impairments reminiscent of immunosenescence are also observed in hyperglycaemia, and in vitro studies have illustrated mechanisms by which elevated glucose can lead to increased dCTLs. This study explored associations between glucose dysregulation and markers of immunosenescence in CMV(+) and CMV(-) individuals. A cross-sectional sample of participants from an occupational cohort study (n = 1,103, mean age 40 years, 88% male) were assessed for HbA(1c) and fasting glucose levels, diabetes, cardiovascular risk factors (e.g. lipids), numbers of circulating effector memory (EM; CD27(-)CD45RA(-)) and CD45RA re-expressing effector memory (EMRA; CD27(-)CD45RA(+)) T cells, and CMV infection status. Self-report and physical examination assessed anthropometric, sociodemographic and lifestyle factors. Among CMV(+) individuals (n = 400), elevated HbA(1c) was associated with increased numbers of EM (B = 2.75, p < 0.01) and EMRA (B = 2.90, p < 0.01) T cells, which was robust to adjustment for age, sex, sociodemographic variables and lifestyle factors. Elevated EM T cells were also positively associated with total cholesterol (B = 0.04, p < 0.05) after applying similar adjustments. No associations were observed in CMV(-) individuals. The present study identified consistent associations of unfavourable glucose and lipid profiles with accumulation of dCTLs in CMV(+) individuals. These results provide evidence that the impact of metabolic risk factors on immunity and health can be co-determined by infectious factors, and provide a novel pathway linking metabolic risk factors with accelerated immunosenescence.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057751472

Download citation: RISBibTeXText

PMID: 26290049

DOI: 10.1007/s00125-015-3731-4


Related references

Increased serum and mRNA levels of RANTES associated with elevated levels of activated CD8+CD38+ T cells in HIV-1 infected individuals. Intervirology 40(4): 263-270, 1997

Microtubule arrays in differentiated cells contain elevated levels of a post-translationally modified form of tubulin. European Journal of Cell Biology 42(2): 288-294, 1986

Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels. Journal of Cell Science 116(Pt 9): 1707-1717, 2003

Elevated serum levels of IgE in P falciparum primed individuals reflect an increased ratio of IL-4 to IFN-gamma producing cells. Scandinavian Journal of Immunology 43(6): 702, 1996

Elevated levels of circulating interleukin-18 in human immunodeficiency virus-infected individuals: role of peripheral blood mononuclear cells and implications for AIDS pathogenesis. Journal of Virology 76(24): 12448-12456, 2002

Elevated C-reactive protein levels in individuals with low high-density lipoprotein cholesterol levels. Metabolism: Clinical and Experimental 54(9): 1266-7; Author Reply 1267, 2005

Elevated plasma levels of IgE in Plasmodium falciparum-primed individuals reflect an increased ratio of IL-4 to interferon-gamma (IFN-gamma)-producing cells. Clinical and Experimental Immunology 109(1): 84-89, 1997

Chronic stress, depression, and cortisol levels as risk indicators of elevated plaque and gingivitis levels in individuals aged 50 years and older. Journal of Periodontology 77(6): 1008-1014, 2006

Slightly elevated B-type natriuretic peptide levels in a non-heart failure range indicate a worse left ventricular diastolic function in individuals with, as compared with individuals without, type 2 diabetes: the Hoorn Study. European Journal of Heart Failure 12(9): 958-965, 2010

Elevated il 6 levels in individuals with hiv infection. Journal of Allergy & Clinical Immunology 85(1 Part 2): 239, 1990

Elevated levels of IgE and lymphomatoid papulosis (subtype B) as background of well-differentiated lymphocyte B cell lymphoma. Revista Clinica Espanola 207(3): 148-149, 2007

Elevated gliadin antibody levels in individuals with schizophrenia. World Journal of Biological Psychiatry 14(7): 509-515, 2013

Elevated cortisol levels in whole saliva in HIV infected individuals. European Journal Of Oral Sciences. 104(3): 322-324, 1996

IgE+ cells in the peripheral blood of atopic, nonatopic, and bee venom-hypersensitive individuals exhibit the phenotype of highly differentiated B cells. Journal of Allergy and Clinical Immunology 95(2): 587-596, 1995