+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Evaluation of Diagnostic Efficiency of Ultrasound Features on Malignant Thyroid Nodules in Chinese Patients

Evaluation of Diagnostic Efficiency of Ultrasound Features on Malignant Thyroid Nodules in Chinese Patients

Chinese Medical Journal 129(15): 1784-1788

The aim of this study was to evaluate the efficacy of ultrasonic features in predicting the malignancy of thyroid nodules in a group of Chinese patients. In all, 762 patients with thyroid nodules (424 malignant and 338 benign) underwent ultrasound (US) check and surgery between March 2011 and July 2014 at Peking University First Hospital were identified. Univariate and receiver operating characteristic (ROC) analyses were performed to calculate the sensitivity, specificity, negative and positive predictive values of each US feature, and the accuracy of their combinations for prediction of malignancy. Patients with malignant nodules were younger and without obvious risk history than those in the benign group (P < 0.001, P = 0.93). No individual US sign was fully predictive of a malignant lesion. The Youden indexes of irregular margins and hypoechogenicity were the first and second highest in all US features, which were 51.9% and 45.2%, respectively. The sensitivity of solid components (89.7%) and hypoechogenicity (89.2%) and the specificity of taller-than-wide shape (98.5%) and microcalcifications (90.6%) were the first and second highest in all US features. Intranodular flow on a color Doppler examination was a weak predictor of malignancy. Under ROC analysis excepting intranodular flow, the 95% confidence interval (CI) of areas under the curves of hypoechogenicity and irregular margins with any one of the US features were overlapped that of five-feature combinations (95% CI: 0.850-0.901). We should be alert with taller-than-wide shape and microcalcifications. Intranodular flow was a weak predictor of malignancy. According to Youden indexes and ROC analysis, irregular margins and hypoechogenicity combined with solid component or taller-than-wide shapes or microcalcifications have a high predicative value for malignant thyroid nodules in Chinese patients.

(PDF emailed within 1 workday: $29.90)

Accession: 057807756

Download citation: RISBibTeXText

PMID: 27453225

Related references

Improvement of diagnostic efficiency in distinguishing the benign and malignant thyroid nodules via conventional ultrasound combined with ultrasound contrast and elastography. Oncology Letters 14(1): 867-871, 2017

Diagnostic Efficiency of Quantitative Contrast-Enhanced Ultrasound Indicators for Discriminating Benign From Malignant Solid Thyroid Nodules. Journal of Ultrasound in Medicine 37(2): 425-437, 2017

Ultrasound Strain Elastography for Circumscribed Solid Thyroid Nodules without Malignant Features Categorized as Indeterminate by B-Mode Ultrasound. Ultrasound in Medicine and Biology 42(10): 2383-2390, 2017

Diagnostic accuracy of ultrasound characteristics in the identification of malignant thyroid nodules. Bmc Research Notes 12(1): 193, 2019

Quantitative evaluation of contrast-enhanced ultrasound after intravenous administration of a microbubble contrast agent for differentiation of benign and malignant thyroid nodules: assessment of diagnostic accuracy. European Radiology 22(6): 1357-1365, 2012

Comparative study on the diagnostic values of different ultrasound technologies for malignant thyroid nodules. Oncology Letters 16(1): 910-914, 2018

Role of thyroid ultrasound in the diagnostic evaluation of thyroid nodules. Best Practice and Research. Clinical Endocrinology and Metabolism 22(6): 913-928, 2008

The diagnostic efficiency of ultrasound in characterization for thyroid nodules: how many criteria are required to predict malignancy?. Medical Ultrasonography 14(1): 24-28, 2012

The diagnostic value of combination of TI-RADS and ultrasound elastography in the differentiation of benign and malignant thyroid nodules. Clinical Imaging 40(5): 913-916, 2016

Can malignant thyroid nodules be distinguished from benign thyroid nodules in children and adolescents by clinical characteristics? A review of 89 pediatric patients with thyroid nodules. Thyroid 25(4): 392-400, 2016

Significance of ultrasound features in predicting malignant solid thyroid nodules: need for fine-needle aspiration. Jpma. Journal of the Pakistan Medical Association 60(10): 848-853, 2011

Development and validation of an ultrasound-based nomogram to improve the diagnostic accuracy for malignant thyroid nodules. European Radiology 2018, 2018

Diagnostic value of ultrasound-guided fine needle aspiration biopsy in malignant thyroid nodules: utility for micronodules. Asian Pacific Journal of Cancer Prevention 15(20): 8613-8616, 2015

Diagnostic Criteria and Accuracy of Categorizing Malignant Thyroid Nodules by Ultrasonography and Ultrasound Elastography with Pathologic Correlation. Ultrasonic Imaging 38(2): 148-158, 2017

Use of diagnostic ultrasound in the evaluation of hypo functioning thyroid nodules. Israel Journal of Medical Sciences 8(11): 1879, 1972