+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Evolutionary biology and the avoidance of antimicrobial resistance

Evolutionary biology and the avoidance of antimicrobial resistance

Evolutionary Applications 2(1): 40-51

Evolutionary biologists have largely left the search for solutions to the drug resistance crisis to biomedical scientists, physicians, veterinarians and public health specialists. We believe this is because the vast majority of professional evolutionary biologists consider the evolutionary science of drug resistance to be conceptually uninteresting. Using malaria as case study, we argue that it is not. We review examples of evolutionary thinking that challenge various fallacies dominating antimalarial therapy, and discuss open problems that need evolutionary insight. These problems are unlikely to be resolved by biomedical scientists ungrounded in evolutionary biology. Involvement by evolutionary biologists in the science of drug resistance requires no intellectual compromises: the problems are as conceptually challenging as they are important.

(PDF emailed within 0-6 h: $19.90)

Accession: 057825168

Download citation: RISBibTeXText

PMID: 25567846

DOI: 10.1111/j.1752-4571.2008.00066.x

Related references

Public health evolutionary biology of antimicrobial resistance: priorities for intervention. Evolutionary Applications 8(3): 223-239, 2015

Three mechanisms of host resistance to microparasites-avoidance, recovery and tolerance-show different evolutionary dynamics. Journal of Theoretical Biology 201(1): 13-23, 1999

Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives. Fems Microbiology Reviews 41(3): 354-373, 2017

The unity of evolutionary biology vols 1 and 2 fourth international congress of systematic and evolutionary biology college park maryland usa june 30 july 7 1990. Dudley, E C The Unity Of Evolutionary Biology, Vols 1 And 2; Fourth International Congress Of Systematic And Evolutionary Biology, College Park, Maryland, Usa, June 30-July 7, 1990 588p (Vol 1); Xiii+461p (Vol 2) Dioscorides Press: Portland, Oregon, Usa Illus Maps 588p (Vol 1), Xiii+461p (Vol 2), 1991

Population biology and evolutionary ecology in France: current state and prospects : Plenary address given at the founding congress of the European Society for Evolutionary Biology, 26 August 1987, in Basel. Journal of Evolutionary Biology 1(3): 211-231, 1988

The unity of evolutionary biology: proceedings of the Fourth International Congress of Systematic and Evolutionary Biology. Volume 1. University of Maryland, College Park, USA, July 1990. Co-hosted by the Smithsonian Institution. Unknown, 1991

Evolutionary biology of metal resistance in Silene vulgaris. Evolutionary Trends in Plants 4(1): 45-51, 1990

Evolutionary biology of starvation resistance: what we have learned from Drosophila. Journal of Evolutionary Biology 20(5): 1655-1664, 2007

Antimicrobial resistance in Campylobacter spp. isolated from Ontario sheep flocks and associations between antimicrobial use and antimicrobial resistance. Zoonoses and Public Health 59(4): 294-301, 2012

How the European Society for Evolutionary Biology and the Journal of Evolutionary Biology were founded. Journal of Evolutionary Biology 21(6): 1449-1451, 2008

Without the Light of Evolution: A Case Study of Resistance and Avoidance in Learning to Teach High School Biology. Science Education 99(3): 549-576, 2015

Link between insulin resistance and hypertension: What is the evidence from evolutionary biology?. Diabetology and Metabolic Syndrome 6(1): 12, 2014

Emergence, spread, and environmental effect of antimicrobial resistance: how use of an antimicrobial anywhere can increase resistance to any antimicrobial anywhere else. Clinical Infectious Diseases 34 Suppl 3: S78-S84, 2002

Presence of antimicrobial resistance and antimicrobial use in sows are risk factors for antimicrobial resistance in their offspring. Microbial Drug Resistance 21(1): 50-58, 2015

Molecular biology of the mechanism of acquisition of antimicrobial-resistance. Nihon Rinsho. Japanese Journal of Clinical Medicine 59(4): 660-665, 2001