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Expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia

Expression of autoantibody against the M2-muscarinic receptor in patients with severe preeclampsia

Zhong Nan Da Xue Xue Bao. Yi Xue Ban 41(7): 707-710

目的:检测M2受体自身抗体在重度子痫前期患者中的表达,探讨其临床意义。方法:选择2013年1月至2015年1月在首都医科大学附属朝阳医院妇产科收治的78例重度子痫前期孕妇为研究对象,并取同期收治的78例正常单胎足月孕妇和60例未妊娠妇女作为对照。采用ELISA方法检测3组妇女血浆中的M2受体自身抗体水平,并分析其在重度子痫前期中的临床意义。结果:重度子痫患者M2受体自身抗体阳性率32.1%(25/78),正常妊娠组为10.3%(8/78),两组阳性率比较差异有统计学意义(P<0.01);未妊娠组阳性率8.3%(5/60),与正常妊娠组比较差异无统计学意义(P>0.05);此外,重度子痫前期患者血清中肌酸激酶浓度为(101.49±142.75) U/L,而正常妊娠组肌酸激酶含量为(57.94.±31.64) U/L,两组比较差异有统计学意义(P<0.05)。结论:M2受体自身抗体在重度子痫前期患者中的表达明显增高,可能与其发病有关。.

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Accession: 057844100

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PMID: 27592575

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