+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

F-BAR family proteins, emerging regulators for cell membrane dynamic changes-from structure to human diseases



F-BAR family proteins, emerging regulators for cell membrane dynamic changes-from structure to human diseases



Journal of Hematology and Oncology 8: 47



Eukaryotic cell membrane dynamics change in curvature during physiological and pathological processes. In the past ten years, a novel protein family, Fes/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain proteins, has been identified to be the most important coordinators in membrane curvature regulation. The F-BAR domain family is a member of the Bin/Amphiphysin/Rvs (BAR) domain superfamily that is associated with dynamic changes in cell membrane. However, the molecular basis in membrane structure regulation and the biological functions of F-BAR protein are unclear. The pathophysiological role of F-BAR protein is unknown. This review summarizes the current understanding of structure and function in the BAR domain superfamily, classifies F-BAR family proteins into nine subfamilies based on domain structure, and characterizes F-BAR protein structure, domain interaction, and functional relevance. In general, F-BAR protein binds to cell membrane via F-BAR domain association with membrane phospholipids and initiates membrane curvature and scission via Src homology-3 (SH3) domain interaction with its partner proteins. This process causes membrane dynamic changes and leads to seven important cellular biological functions, which include endocytosis, phagocytosis, filopodium, lamellipodium, cytokinesis, adhesion, and podosome formation, via distinct signaling pathways determined by specific domain-binding partners. These cellular functions play important roles in many physiological and pathophysiological processes. We further summarize F-BAR protein expression and mutation changes observed in various diseases and developmental disorders. Considering the structure feature and functional implication of F-BAR proteins, we anticipate that F-BAR proteins modulate physiological and pathophysiological processes via transferring extracellular materials, regulating cell trafficking and mobility, presenting antigens, mediating extracellular matrix degradation, and transmitting signaling for cell proliferation.

(PDF emailed within 0-6 h: $19.90)

Accession: 057851820

Download citation: RISBibTeXText

PMID: 25956236

DOI: 10.1186/s13045-015-0144-2


Related references

Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death. Advances in Experimental Medicine and Biology 406: 99-112, 1996

The R-spondin family of proteins: emerging regulators of WNT signaling. International Journal of Biochemistry and Cell Biology 44(12): 2278-2287, 2013

The Muscleblind family of proteins: an emerging class of regulators of developmentally programmed alternative splicing. Differentiation; Research in Biological Diversity 74(2-3): 65-80, 2006

Phosphorescent analysis of the structural and dynamic state of membrane cell proteins in oncological diseases. Vyestsi Akademii Navuk BSSR Syeryya Biyalahichnykh Navuk (3): 54-56, 1989

Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. Journal of Molecular Biology 223(3): 683-704, 1992

The CCN family of cell growth regulators: a new family of normal and pathologic cell growth and differentiation regulators: lessons from the first international workshop on CCN gene family. Bulletin du Cancer 88(7): 645-649, 2001

The MARKS family of protein kinase C substrates Versatile regulators of actin structure at the membrane. FASEB Journal 12(4): A358, March 17, 1998

Mouse Ly-6 proteins and their extended family: markers of cell differentiation and regulators of cell signaling. Archivum Immunologiae et Therapiae Experimentalis 52(4): 255-266, 2004

The Bcl-2 family of proteins: regulators of cell death and survival. Trends in Cell Biology 4(11): 399-403, 1994

Bcl-2 family proteins: master regulators of cell survival. Biomolecular Concepts 7(4): 259-270, 2017

The verprolin family of proteins: regulators of cell morphogenesis and endocytosis. Febs Letters 579(24): 5253-5259, 2005

A Bioinformatics Analysis Reveals a Group of MocR Bacterial Transcriptional Regulators Linked to a Family of Genes Coding for Membrane Proteins. Biochemistry Research International 2016: 4360285, 2016

Human cytomegalovirus induces a perinuclear structure containing host cell integral membrane proteins, viral tegument proteins and viral DNA. Biophysical Journal 86(1): 587a, January, 2004

Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control. Cell Cycle 11(18): 3389-3394, 2013

Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins?. Developmental Cell 2(1): 6-7, 2002